| Gene Symbol |
UFSP2
|
| Entrez Gene |
55325
|
| Alt Symbol |
C4orf20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UFM1-specific peptidase 2
|
| Other Description |
ufm1-specific protease 2
|
| Swissprots |
Q9NUQ7 Q6IA77 Q96FS3
|
| Accessions |
EAX04645 EAX04646 Q9NUQ7 AK002062 BAA92064 AK091635 BAG52396 BC010493 AAH10493 BF735169 BP264462 CA432183 CR457278 CAG33559 DA537391 XM_011532090 XP_011530392 NM_018359 NP_060829 NR_028085
|
| Function |
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation. {ECO:0000269|PubMed:25219498}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}.
|