Gene Symbol | UFSP2 |
---|---|
Entrez Gene | 55325 |
Alt Symbol | C4orf20 |
Species | Human |
Gene Type | protein-coding |
Description | UFM1-specific peptidase 2 |
Other Description | ufm1-specific protease 2 |
Swissprots | Q9NUQ7 Q6IA77 Q96FS3 |
Accessions | EAX04645 EAX04646 Q9NUQ7 AK002062 BAA92064 AK091635 BAG52396 BC010493 AAH10493 BF735169 BP264462 CA432183 CR457278 CAG33559 DA537391 XM_011532090 XP_011530392 NM_018359 NP_060829 NR_028085 |
Function | Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation. {ECO:0000269|PubMed:25219498}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. |