| Gene Symbol |
PCDH8
|
| Entrez Gene |
5100
|
| Alt Symbol |
ARCADLIN, PAPC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protocadherin 8
|
| Other Description |
protocadherin-8
|
| Swissprots |
Q5TAN1 B4DMV7 Q5TAN2 O95206 Q96SF1 Q8IYE9
|
| Accessions |
EAW52049 EAW52050 EAW52051 O95206 AF061573 AAC70009 AK293747 BAG57169 AK297652 BAG60019 AY013873 AAK21986 BC036025 AAH36025 DQ893339 ABM84265 NM_002590 NP_002581 NM_032949 NP_116567
|
| Function |
Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Note=Also expressed in neuronal cell bodies. Localized to excitatory, but not with inhibitory, synapses. {ECO:0000250}.
|