| Gene Symbol |
NKRF
|
| Entrez Gene |
55922
|
| Alt Symbol |
ITBA4, NRF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NFKB repressing factor
|
| Other Description |
NF-kappa-B-repressing factor|transcription factor NRF
|
| Swissprots |
O15226 Q4VC41 G3V1N1 Q9UJ91
|
| Accessions |
EAW89859 EAW89860 O15226 AA845622 AJ011812 CAB56459 AL539002 AY208891 AAP43025 BC040379 AAH40379 BC047878 AAH47878 BC068514 AAH68514 EF158333 ABM16955 EF165090 ABM55375 EF165091 ABM55376 EF165092 ABM55377 EF165093 ABM55378 EF165094 ABM55379 EF165095 ABM55380 EF216688 ABN11234 EF216689 ABN11235 Y07707 CAA68976 XM_011531365 XP_011529667 NM_001173487 NP_001166958 NM_001173488 NP_001166959 NM_017544 NP_060014
|
| Function |
Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. {ECO:0000269|PubMed:12381793}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
|
| Tissue Specificity |
Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.
|