Gene Symbol | NKRF |
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Entrez Gene | 55922 |
Alt Symbol | ITBA4, NRF |
Species | Human |
Gene Type | protein-coding |
Description | NFKB repressing factor |
Other Description | NF-kappa-B-repressing factor|transcription factor NRF |
Swissprots | O15226 Q4VC41 G3V1N1 Q9UJ91 |
Accessions | EAW89859 EAW89860 O15226 AA845622 AJ011812 CAB56459 AL539002 AY208891 AAP43025 BC040379 AAH40379 BC047878 AAH47878 BC068514 AAH68514 EF158333 ABM16955 EF165090 ABM55375 EF165091 ABM55376 EF165092 ABM55377 EF165093 ABM55378 EF165094 ABM55379 EF165095 ABM55380 EF216688 ABN11234 EF216689 ABN11235 Y07707 CAA68976 XM_011531365 XP_011529667 NM_001173487 NP_001166958 NM_001173488 NP_001166959 NM_017544 NP_060014 |
Function | Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. {ECO:0000269|PubMed:12381793}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. |
Tissue Specificity | Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney. |
Human NKRF full length protein - ab132717 from Abcam
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NKRF / NRF Antibody Blocking Peptide - LS-E14183 from LifeSpan Bioscience
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NKRF / NRF Antibody Blocking Peptide - LS-E8363 from LifeSpan Bioscience
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NKRF / NRF Antibody Blocking Peptide - LS-E12803 from LifeSpan Bioscience
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NKRF / NRF Antibody Blocking Peptide - LS-E12802 from LifeSpan Bioscience
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NKRF Recombinant Protein - H00055922-P01 from Novus Biologicals
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Recombinant Human NKRF Protein - H00055922-Q01 from Novus Biologicals
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NKRF-Antibody-Center-Blocking-Peptide - BP6660c from Abgent, a WuXi AppTec company
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Human NKRF protein - orb244406 from Biorbyt
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NKRF - H00055922-P01-10 from Acris Antibodies
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NKRF - H00055922-P01-25 from Acris Antibodies
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NKRF - H00055922-Q01-10 from Acris Antibodies
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NKRF - H00055922-Q01-25 from Acris Antibodies
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NKRF fusion protein - Ag6374 from Proteintech Group
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NKRF fusion protein - Ag6252 from Proteintech Group
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Recombinant Human NKRF, His-tagged - NKRF-29050TH from Creative Biomart
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Recombinant Human NKRF, His-tagged - NKRF-1302H from Creative Biomart
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Recombinant NFKB Repressing Factor (NKRF) - RPH536Hu01 from Uscn Life Science Inc.
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Recombinant NFKB Repressing Factor (NKRF) - RPH536Hu01 from Cloud-clone
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Recombinant human NF-kappa-B-repressing factor protein - CSB-EP015836HU CSB-BP015836HU CSB-MP015836HU from Cusabio
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Recombinant human NF-kappa-B-repressing factor protein - CSB-YP015836HU from Cusabio
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Recombinant Human NF-kappa-B-repressing factor(NKRF) - CSB-YP015836HU CSB-EP015836HU CSB-BP015836HU CSB-MP015836HU from Cusabio
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NF-kappa-B-repressing factor protein - RPC140937 from Biomatik
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NFKB Repressing Factor Protein (Recombinant) - abx168193 from Abbexa
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NKRF - TP308507 from Acris Antibodies
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