Gene Symbol | BMPR1B |
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Entrez Gene | 658 |
Alt Symbol | ALK-6, ALK6, CDw293 |
Species | Human |
Gene Type | protein-coding |
Description | bone morphogenetic protein receptor, type IB |
Other Description | BMP type-1B receptor|BMPR-1B|activin receptor-like kinase 6|bone morphogenetic protein receptor type-1B|serine/threonine receptor kinase |
Swissprots | O00238 B4DSV1 B2R953 P78366 |
Accessions | EAX06060 O00238 AK293008 BAF85697 AK299930 BAG61763 AK313642 BAG36400 AW299723 BC047773 AAH47773 BC069796 AAH69796 BC069803 AAH69803 D89675 BAA19765 U89326 AAC28131 XM_011532201 XP_011530503 XM_011532202 XP_011530504 NM_001203 NP_001194 NM_001256792 NP_001243721 NM_001256793 NP_001243722 NM_001256794 NP_001243723 |
Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells |
Active human BMPR1B protein fragment - ab107949 from Abcam
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Active human BMPR1B protein fragment - ab157348 from Abcam
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Human BMPR1B full length protein - ab131989 from Abcam
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Human BMPR1B protein fragment - ab152236 from Abcam
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Human BMPR1B protein fragment - ab152237 from Abcam
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Human BMPR1B protein fragment - ab202162 from Abcam
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ALK-6 / BMPR1B Antibody Blocking Peptide - LS-E1379 from LifeSpan Bioscience
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ALK-6 / BMPR1B Antibody Blocking Peptide - LS-E4036 from LifeSpan Bioscience
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ALK-6 / BMPR1B Antibody Blocking Peptide - LS-E6798 from LifeSpan Bioscience
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ALK-6 / BMPR1B Antibody Blocking Peptide - LS-E6797 from LifeSpan Bioscience
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ALK-6 / BMPR1B Antibody Blocking Peptide - LS-E6799 from LifeSpan Bioscience
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BMPR-IB/ALK-6 Recombinant Protein - H00000658-P01 from Novus Biologicals
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BMPR-IB/ALK-6 Partial Recombinant Protein - H00000658-Q01 from Novus Biologicals
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BMPR-IB/ALK-6 Partial Recombinant Protein - H00000658-Q03 from Novus Biologicals
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BMPR-IB/ALK-6 Recombinant Protein - H00000658-G01 from Novus Biologicals
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BMPR-IB/ALK-6 Peptide - P0794 from Novus Biologicals
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BMPR1B-Antibody-Center-Blocking-peptide - BP12034c from Abgent, a WuXi AppTec company
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BMPR1B-Antibody-N-term-D17-Blocking-Peptide - BP2005c from Abgent, a WuXi AppTec company
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BMPR1B-Antibody-C-term-Blocking-Peptide - BP2005b from Abgent, a WuXi AppTec company
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BMPR1B-Antibody-N-term-K15-Blocking-Peptide - BP2005a from Abgent, a WuXi AppTec company
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Recombinant Human BMPR-IB/ALK-6 Fc Chimera, CF - 505-PR-100 from R&D Systems
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Human ALK-6 protein - orb138164 from Biorbyt
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Human ALK-6 protein (GST Tag) - orb138163 from Biorbyt
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BMPR1B protein - 80R-4242 from Fitzgerald
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CDw293 / BMPR1B (14-126, His-tag) - AR51924PU-N from Acris Antibodies
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