RORA

Gene Symbol RORA
Entrez Gene 6095
Alt Symbol NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA
Species Human
Gene Type protein-coding
Description RAR-related orphan receptor A
Other Description ROR-alpha|nuclear receptor ROR-alpha|nuclear receptor RZR-alpha|nuclear receptor subfamily 1 group F member 1|retinoic acid receptor-related orphan receptor alpha|retinoid-related orphan receptor alpha|thyroid hormone nuclear receptor alpha variant 4|transcription factor RZR-alpha
Swissprots Q96H83 P35399 Q495X4 P35398 P45445 P35397
Accessions CAH05309 CAH05310 CAH05311 CAH05312 EAW77593 EAW77594 EAW77595 EAW77596 P35398 AB209916 BAD93153 AB307694 BAH02285 AK055969 AL530219 AL532048 AL832164 BC008831 AAH08831 BC033285 BC048264 BC100987 AAI00988 BC100988 AAI00989 BC100989 AAI00990 BC100990 AAI00991 BG705319 DB482516 HQ692818 ADZ17329 HQ709174 ADZ17381 L14611 AAA02963 U04897 AAA62658 U04898 AAA62659 U04899 AAA62660 XM_005254584 XP_005254641 XM_011521873 XP_011520175 XM_011521874 XP_011520176 XM_011521875 XP_011520177 XM_011521876 XP_011520178 XM_011521877 XP_011520179 XM_011521878 XP_011520180 XM_011521879 XP_011520181 NM_002943 NP_002934 NM_134260 NP_599022 NM_134261 NP_599023 NM_134262 NP_599024
Function Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cel
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:18005000, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046}.
Tissue Specificity Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff). {ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:7916608}.
Top Pathways Circadian rhythm, Inflammatory bowel disease (IBD)

Human Phosphotyrosine ROR1 ELISA kit - orb159154 from Biorbyt

Category ELISA Kit
Prices $740.00, $1,258.00, $2,678.00
Sizes 96 well, 192 assays, 480 assays

Nuclear receptor ROR-alpha (RORA), Human, ELISA Kit - CSB-EL020069HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 4.68 pg/ml
Range 18.75 pg/ml-1200 pg/ml

Tyrosine-protein kinase transmembrane receptor ROR1, ROR1, Human, ELISA Kit - E1118h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

RAR-related orphan receptor A, ELISA Kit - MBS910208 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 4.68 pg/ml
Range 18.75 pg/ml-1200 pg/ml

Human Nuclear receptor ROR-alpha(RORA) ELISA kit - CSB-EL020069HU from Cusabio

Category ELISA Kit
Sensitivity 4.68 pg/ml
Range 18.75 pg/ml-1200 pg/ml

Human ROR1 ELISA Kit - abx152979 from Abbexa

Category ELISA Kit
Sensitivity 0.054 ng/ml
Range 0.156 ng/ml - 10 ng/ml

ELISA Kit for RAR Related Orphan Receptor Alpha (RORa) - SED947Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.056ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for RAR Related Orphan Receptor Alpha (RORa) - SED947Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.056ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human ROR1 ELISA Kit - orb320031 from Biorbyt

Category ELISA Kit
Prices $1,148.00, $1,981.00, $4,284.00
Sizes 96 assays, 192 assays, 480 assays

Human ROR1 ELISA Kit - abx571929 from Abbexa

Category ELISA Kit
Sensitivity 0.054 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Human Nuclear receptor ROR-alpha (RORA) ELISA Kit - EKC34857 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,288.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 4.68 pg/ml
Range 18.75 pg/ml-1200 pg/ml

Custom Human ROR2 ELISA Kit - orb384731 from Biorbyt

Category ELISA Kit
Prices $1,411.00, $2,448.00, $5,321.00
Sizes 96 assays, 192 assays, 480 assays

Human RORA ELISA Kit - E032832 from Biobool

Category ELISA Kit
Sensitivity 4.68 pg/ml

Human ROR1 ELISA Kit - E033014 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of ROR1 is typically less than 0.058ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two

Human ROR2 ELISA Kit - E096303 from Biobool

Category ELISA Kit

RORA ELISA Kit (Human) (OKCD00411) - OKCD00411 from Aviva Systems Biology

Category ELISA Kit
Prices $545.00
Sizes 96 wells
Sensitivity < 0.056 ng/mL
Range 0.156-10 ng/mL

anti-ROR1 antibody - ARG55694 from Arigo Biolaboratories

Category ELISA Kit

anti-ROR1 antibody - ARG65743 from Arigo Biolaboratories

Category ELISA Kit

Human RORA / ROR Alpha ELISA Kit (Sandwich ELISA) - LS-F39038 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 0.056
Range 0.156-10 ng/ml
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