RORA

Gene Symbol RORA
Entrez Gene 6095
Alt Symbol NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA
Species Human
Gene Type protein-coding
Description RAR-related orphan receptor A
Other Description ROR-alpha|nuclear receptor ROR-alpha|nuclear receptor RZR-alpha|nuclear receptor subfamily 1 group F member 1|retinoic acid receptor-related orphan receptor alpha|retinoid-related orphan receptor alpha|thyroid hormone nuclear receptor alpha variant 4|transcription factor RZR-alpha
Swissprots Q96H83 P35399 Q495X4 P35398 P45445 P35397
Accessions CAH05309 CAH05310 CAH05311 CAH05312 EAW77593 EAW77594 EAW77595 EAW77596 P35398 AB209916 BAD93153 AB307694 BAH02285 AK055969 AL530219 AL532048 AL832164 BC008831 AAH08831 BC033285 BC048264 BC100987 AAI00988 BC100988 AAI00989 BC100989 AAI00990 BC100990 AAI00991 BG705319 DB482516 HQ692818 ADZ17329 HQ709174 ADZ17381 L14611 AAA02963 U04897 AAA62658 U04898 AAA62659 U04899 AAA62660 XM_005254584 XP_005254641 XM_011521873 XP_011520175 XM_011521874 XP_011520176 XM_011521875 XP_011520177 XM_011521876 XP_011520178 XM_011521877 XP_011520179 XM_011521878 XP_011520180 XM_011521879 XP_011520181 NM_002943 NP_002934 NM_134260 NP_599022 NM_134261 NP_599023 NM_134262 NP_599024
Function Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cel
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:18005000, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046}.
Tissue Specificity Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff). {ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:7916608}.
Top Pathways Circadian rhythm, Inflammatory bowel disease (IBD)

RORα CRISPR/Cas9 KO Plasmid (h) - sc-400578 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RORα HDR Plasmid (h) - sc-400578-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RORα Double Nickase Plasmid (h) - sc-400578-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RORα Double Nickase Plasmid (h2) - sc-400578-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RORα CRISPR Activation Plasmid (h) - sc-400578-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RORα CRISPR Activation Plasmid (h2) - sc-400578-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RORα Lentiviral Activation Particles (h) - sc-400578-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RORα Lentiviral Activation Particles (h2) - sc-400578-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RORα siRNA (h) - sc-38862 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα shRNA Plasmid (h) - sc-38862-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα shRNA (h) Lentiviral Particles - sc-38862-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα1 siRNA (h) - sc-38864 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα1 shRNA Plasmid (h) - sc-38864-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα1 shRNA (h) Lentiviral Particles - sc-38864-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα2 siRNA (h) - sc-38866 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα2 shRNA Plasmid (h) - sc-38866-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα2 shRNA (h) Lentiviral Particles - sc-38866-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα3 siRNA (h) - sc-38868 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα3 shRNA Plasmid (h) - sc-38868-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RORα3 shRNA (h) Lentiviral Particles - sc-38868-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ROR2 RNAi - H00004920-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ROR alpha/NR1F1 RNAi - H00006095-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

ROR alpha/NR1F1 RNAi - H00006095-R04 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

ROR alpha/NR1F1 RNAi - H00006095-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU072741 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg
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