RORA

Gene Symbol RORA
Entrez Gene 6095
Alt Symbol NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA
Species Human
Gene Type protein-coding
Description RAR-related orphan receptor A
Other Description ROR-alpha|nuclear receptor ROR-alpha|nuclear receptor RZR-alpha|nuclear receptor subfamily 1 group F member 1|retinoic acid receptor-related orphan receptor alpha|retinoid-related orphan receptor alpha|thyroid hormone nuclear receptor alpha variant 4|transcription factor RZR-alpha
Swissprots Q96H83 P35399 Q495X4 P35398 P45445 P35397
Accessions CAH05309 CAH05310 CAH05311 CAH05312 EAW77593 EAW77594 EAW77595 EAW77596 P35398 AB209916 BAD93153 AB307694 BAH02285 AK055969 AL530219 AL532048 AL832164 BC008831 AAH08831 BC033285 BC048264 BC100987 AAI00988 BC100988 AAI00989 BC100989 AAI00990 BC100990 AAI00991 BG705319 DB482516 HQ692818 ADZ17329 HQ709174 ADZ17381 L14611 AAA02963 U04897 AAA62658 U04898 AAA62659 U04899 AAA62660 XM_005254584 XP_005254641 XM_011521873 XP_011520175 XM_011521874 XP_011520176 XM_011521875 XP_011520177 XM_011521876 XP_011520178 XM_011521877 XP_011520179 XM_011521878 XP_011520180 XM_011521879 XP_011520181 NM_002943 NP_002934 NM_134260 NP_599022 NM_134261 NP_599023 NM_134262 NP_599024
Function Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cel
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:18005000, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046}.
Tissue Specificity Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff). {ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:7916608}.
Top Pathways Circadian rhythm, Inflammatory bowel disease (IBD)

RORα (C-12) - sc-26380 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RORα (C-12): sc-26380. Western blot analysis of RORα expression in L6 (A), KNRK (B) and LNCaP (C) whole cell lysates.

RORα (C-16) - sc-6062 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RORα (C-16): sc-6062. Western blot analysis of RORα expression in mouse cerebellum extract.

RORα (H-65) - sc-28612 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RORα (H-65): sc-28612. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing nuclear staining of decidual and trophoblastic cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

RORα (X-23) - sc-133973 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
RORα (X-23): sc-133973. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing nuclear and cytoplasmic localization.

RORα1 (S-12) - sc-26377 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RORα1 (S-12): sc-26377. Immunofluorescence staining of methanol-fixed SCC-4 cells showing nuclear localization.

RORα2 (D-14) - sc-26379 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RORα3 (Q-13) - sc-26378 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ROR alpha + beta + gamma antibody [H3925] - ab41942 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone H3925
Ab41942 at 10 µg/ml staining rat cerebrum nerve cells.

Anti-ROR alpha antibody - ab70061 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ROR alpha antibody (ab70061) at 1/500 dilutionLane 1 : extract from HeLa cellsLane 2 : extract from COS-7 cellsLane 3 : extract from COS-7 cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-ROR alpha antibody - ab82289 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells labelling ROR alpha with ab82289. Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with ab82289 (1:25, 1 h at 37℃). Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used as the secondary antibody (1:400, 50 min at 37℃). Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃) and nuclei were counterstained with DAPI (blue) (10 µg/ml, 10 min). ROR alpha immunoreactivity is localized to the nucleus.

Anti-ROR alpha antibody - ab16367 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ROR alpha antibody - Carboxyterminal end - ab71016 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ROR alpha antibody - Carboxyterminal end (ab71016) at 1/300 dilution + Jurkat cell line lysates at 35 µg

Anti-RORA / ROR Alpha Antibody (aa101-150) - LS-C40522 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-RORA / ROR Alpha Antibody (aa201-250) - LS-C40523 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RORA antibody LS-C40523 Western blot of HepG2 cell lysate.

Anti-RORA / ROR Alpha Antibody (aa50-99) - LS-C31274 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
RORA antibody LS-C31274 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-RORA / ROR Alpha Antibody (aa288-337) - LS-C109966 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RORA antibody LS-C109966 Western blot of 721_B cell lysate.

Anti-RORA / ROR Alpha Antibody (aa36-85) - LS-C111052 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RORA antibody LS-C111052 Western blot of Fetal Lung lysate.

Anti-RORA / ROR Alpha Antibody (aa36-85) - LS-C112353 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RORA antibody LS-C112353 Western blot of MCF7 cell lysate.

Anti-RORA / ROR Alpha Antibody (aa220-270) - LS-C148467 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ROR alpha in human skeletal muscle lysate in the 1) absence and 2) presence of immunizing peptide using LS-C148467 at 0.025 ug/ml.

Anti-RORA / ROR Alpha Antibody (Hinge Domain) IHC-plus™ - LS-A2337 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ROR Alpha / RORA antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A2337 dilution 11-17 ug/ml.

Anti-RORA / ROR Alpha Antibody (aa293-523) - LS-C191248 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-RORA / ROR Alpha Antibody (aa239-288) - LS-C40524 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
RORA antibody LS-C40524 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-RORA / ROR Alpha Antibody (Thr216, AP) - LS-C282024 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RORA / ROR Alpha Antibody (Thr216, APC) - LS-C282028 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RORA / ROR Alpha Antibody (Thr216, Biotin) - LS-C282029 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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