| Gene Symbol | RORA |
|---|---|
| Entrez Gene | 6095 |
| Alt Symbol | NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAR-related orphan receptor A |
| Other Description | ROR-alpha|nuclear receptor ROR-alpha|nuclear receptor RZR-alpha|nuclear receptor subfamily 1 group F member 1|retinoic acid receptor-related orphan receptor alpha|retinoid-related orphan receptor alpha|thyroid hormone nuclear receptor alpha variant 4|transcription factor RZR-alpha |
| Swissprots | Q96H83 P35399 Q495X4 P35398 P45445 P35397 |
| Accessions | CAH05309 CAH05310 CAH05311 CAH05312 EAW77593 EAW77594 EAW77595 EAW77596 P35398 AB209916 BAD93153 AB307694 BAH02285 AK055969 AL530219 AL532048 AL832164 BC008831 AAH08831 BC033285 BC048264 BC100987 AAI00988 BC100988 AAI00989 BC100989 AAI00990 BC100990 AAI00991 BG705319 DB482516 HQ692818 ADZ17329 HQ709174 ADZ17381 L14611 AAA02963 U04897 AAA62658 U04898 AAA62659 U04899 AAA62660 XM_005254584 XP_005254641 XM_011521873 XP_011520175 XM_011521874 XP_011520176 XM_011521875 XP_011520177 XM_011521876 XP_011520178 XM_011521877 XP_011520179 XM_011521878 XP_011520180 XM_011521879 XP_011520181 NM_002943 NP_002934 NM_134260 NP_599022 NM_134261 NP_599023 NM_134262 NP_599024 |
| Function | Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cel |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:18005000, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046}. |
| Tissue Specificity | Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff). {ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:7916608}. |
| Top Pathways | Circadian rhythm, Inflammatory bowel disease (IBD) |