CDK4

Gene Symbol	CDK4
Entrez Gene	1019
Alt Symbol	CMM3, PSK-J3
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 4
Other Description	cell division protein kinase 4
Swissprots	Q6FG61 P11802 B4DNF9 O00576 B2R9A0
Accessions	AAC39521 AAC50506 AAD13991 AAM23014 CDI30203 CDM63717 EAW97058 EAW97059 EAW97060 EAW97061 EAW97062 P11802 AK297901 BAG60221 AK310724 AK313701 BAG36447 BC003644 AAH03644 BC005864 AAH05864 BC010153 AAH10153 BC015669 AAH15669 BI832658 BQ773564 CR407668 CAG28596 CR542247 CAG47043 DQ893137 ABM84063 DQ896420 ABM87419 M14505 AAA35673 U79269 AAB50213 Z48970 CAA88834 NM_000075 NP_000066 NM_052984
Function	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:9003781}.
Subcellular Location	Cytoplasm. Nucleus. Membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
Top Pathways	p53 signaling pathway, Tight junction, PI3K-Akt signaling pathway, T cell receptor signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CDK4-Over-expression-Lysate - LY11464a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CDK4 293T Cell Transient Overexpression Lysate(Denatured) - H00001019-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CDK4 293 Cell Lysate - 400119 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CDK4 Overexpression Lysate (Denatured) - H00001019-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

CDK4 Overexpression Lysate (Native) - NBL1-09039 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Cdk4 (h3): 293 Lysate - sc-158369 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CDK4 Over-expression Lysate Product - GWB-9B400A from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human CDK4 / CMM3 Insect Cell Lysate (WB positive control) - 10732-H09BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CDK4 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb174966 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

CDK4 Overexpression Lysate (Denatured) - H00001019-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human CDK4 Knockdown Stable Cell Line - CSC-DC002874 from Creative biogene Category Cell Line Species Human

CDK4 Knockout Cell Line-HeLa - CSC-RT1960 from Creative biogene Category Cell Line Species Human

CDK4 KO Cell Lysate-HeLa - CLKO-1819 from Creative biogene Category Cell Lysate

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