| Gene Symbol | CDK4 |
|---|---|
| Entrez Gene | 1019 |
| Alt Symbol | CMM3, PSK-J3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase 4 |
| Other Description | cell division protein kinase 4 |
| Swissprots | Q6FG61 P11802 B4DNF9 O00576 B2R9A0 |
| Accessions | AAC39521 AAC50506 AAD13991 AAM23014 CDI30203 CDM63717 EAW97058 EAW97059 EAW97060 EAW97061 EAW97062 P11802 AK297901 BAG60221 AK310724 AK313701 BAG36447 BC003644 AAH03644 BC005864 AAH05864 BC010153 AAH10153 BC015669 AAH15669 BI832658 BQ773564 CR407668 CAG28596 CR542247 CAG47043 DQ893137 ABM84063 DQ896420 ABM87419 M14505 AAA35673 U79269 AAB50213 Z48970 CAA88834 NM_000075 NP_000066 NM_052984 |
| Function | Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:9003781}. |
| Subcellular Location | Cytoplasm. Nucleus. Membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus. |
| Top Pathways | p53 signaling pathway, Tight junction, PI3K-Akt signaling pathway, T cell receptor signaling pathway, Viral carcinogenesis |