MLF1

Gene Symbol	MLF1
Entrez Gene	4291
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	myeloid leukemia factor 1
Other Description	myelodysplasia-myeloid leukemia factor 1
Swissprots	P58340 Q2TLE3 Q2TLE5 Q8N8F8 E9PEU9 Q96MH1
Accessions	EAW78685 EAW78686 EAW78687 EAW78688 EAW78689 EAW78690 P58340 AA707847 AK056948 BAB71320 AK096889 BAC04885 AK297488 BAG59906 AK315402 BAG37795 AY848700 AAX46015 AY848701 AAX46016 AY848702 AAX46017 BC007045 AAH07045 BC095437 BU619178 BX641078 BX647666 CAI46058 DB455518 L49054 AAA99997 XM_005247479 XP_005247536 XM_005247480 XP_005247537 XM_006713645 XP_006713708 XM_011512852 XP_011511154 XM_011512853 XP_011511155 XM_011512854 XP_011511156 NM_001130156 NP_001123628 NM_001130157 NP_001123629 NM_001195432 NP_001182361 NM_001195433 NP_001182362 NM_001195434 NP_001182363 NM_022443 NP_071888
Function	Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:15861129}.
Subcellular Location	Cytoplasm. Nucleus. Note=In non- hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.
Tissue Specificity	Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MLF1 (D-1) - sc-514294 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MLF1 (A-8) - sc-514304 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MLF1 (E-17) - sc-48043 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MLF1 (H-135) - sc-134895 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

MLF1 (G-16) - sc-48044 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MLF1 (T-15) - sc-48046 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Myeloid leukemia factor 1 antibody - ab103099 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Myeloid leukemia factor 1 antibody - ab70211 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Myeloid leukemia factor 1 antibody - ab202389 from Abcam Prices $359.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Myeloid leukemia factor 1 antibody - ab84942 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Myeloid leukemia factor 1 antibody - ab172068 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Myeloid leukemia factor 1 antibody [3A3] - ab128108 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3A3

Anti-Myeloid leukemia factor 1 antibody - N-terminal - ab175534 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MLF1 Antibody (clone 2H10) - LS-C173969 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2H10

Anti-MLF1 Antibody (aa215-244, Azide-free, HRP) - LS-C263220 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MLF1 Antibody (clone 2C10) - LS-C175132 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2C10

Anti-MLF1 Antibody (C-Terminus) - LS-C287435 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MLF1 Antibody (aa215-244, AP) - LS-C264267 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MLF1 Antibody - LS-C309014 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-MLF1 Antibody - LS-C310989 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MLF1 Antibody (clone 3B8) - LS-C173986 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3B8

Anti-MLF1 Antibody - LS-C310993 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MLF1 Antibody (aa222-252) - LS-C323023 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MLF1 Antibody (aa194-239) - LS-C313827 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MLF1 Antibody (clone 3E7) - LS-C337759 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3E7

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