MLF1

Gene Symbol	MLF1
Entrez Gene	4291
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	myeloid leukemia factor 1
Other Description	myelodysplasia-myeloid leukemia factor 1
Swissprots	P58340 Q2TLE3 Q2TLE5 Q8N8F8 E9PEU9 Q96MH1
Accessions	EAW78685 EAW78686 EAW78687 EAW78688 EAW78689 EAW78690 P58340 AA707847 AK056948 BAB71320 AK096889 BAC04885 AK297488 BAG59906 AK315402 BAG37795 AY848700 AAX46015 AY848701 AAX46016 AY848702 AAX46017 BC007045 AAH07045 BC095437 BU619178 BX641078 BX647666 CAI46058 DB455518 L49054 AAA99997 XM_005247479 XP_005247536 XM_005247480 XP_005247537 XM_006713645 XP_006713708 XM_011512852 XP_011511154 XM_011512853 XP_011511155 XM_011512854 XP_011511156 NM_001130156 NP_001123628 NM_001130157 NP_001123629 NM_001195432 NP_001182361 NM_001195433 NP_001182362 NM_001195434 NP_001182363 NM_022443 NP_071888
Function	Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:15861129}.
Subcellular Location	Cytoplasm. Nucleus. Note=In non- hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.
Tissue Specificity	Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Myeloid leukemia factor 1 full length protein - ab40569 from Abcam Category Protein Source E. coli Species Human

MLF1 Antibody Blocking Peptide - LS-E19455 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MLF1 Antibody Blocking Peptide - LS-E8410 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MLF1 Antibody Blocking Peptide - LS-E8411 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Myeloid leukemia factor 1 Recombinant Protein - H00004291-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Myeloid leukemia factor 1 Protein - NBP1-50985 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Mlf1-Antibody-N-term-S34-Blocking-Peptide - BP18730a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLF1-Antibody-C-term-Blocking-Peptide - BP6716b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLF1-Antibody-N-term-Blocking-Peptide - BP6716a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLF1 Protein (OPPA00169) - OPPA00169 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human MLF1 protein - orb168842 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

MLF1 peptide - orb217604 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

MLF1 Blocking Peptide - 33R-3521 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MLF1 protein (His tag) - 80R-1664 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

MLF1 Blocking Peptide - abx062935 from Abbexa Category Peptide Species Human, Mouse, Rat

Myeloid leukemia factor 1 (1-268, His-tag) - AR09846PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Myeloid leukemia factor 1 (1-268, His-tag) - AR09846PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Myeloid leukemia factor 1 - H00004291-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Myeloid leukemia factor 1 - H00004291-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Myeloid Leukemia Factor 1, Human Recombinant - 228-12820-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Myeloid Leukemia Factor 1 - 228-12820-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Myeloid Leukemia Factor 1 - 228-12820-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

MLF1, 1-268aa, Human, His tag, E.coli - 01-P0906 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

MLF1 fusion protein - ag3727 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MLF1 Human - PRPS-107 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Search more