| Gene Symbol | MLF1 |
|---|---|
| Entrez Gene | 4291 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | myeloid leukemia factor 1 |
| Other Description | myelodysplasia-myeloid leukemia factor 1 |
| Swissprots | P58340 Q2TLE3 Q2TLE5 Q8N8F8 E9PEU9 Q96MH1 |
| Accessions | EAW78685 EAW78686 EAW78687 EAW78688 EAW78689 EAW78690 P58340 AA707847 AK056948 BAB71320 AK096889 BAC04885 AK297488 BAG59906 AK315402 BAG37795 AY848700 AAX46015 AY848701 AAX46016 AY848702 AAX46017 BC007045 AAH07045 BC095437 BU619178 BX641078 BX647666 CAI46058 DB455518 L49054 AAA99997 XM_005247479 XP_005247536 XM_005247480 XP_005247537 XM_006713645 XP_006713708 XM_011512852 XP_011511154 XM_011512853 XP_011511155 XM_011512854 XP_011511156 NM_001130156 NP_001123628 NM_001130157 NP_001123629 NM_001195432 NP_001182361 NM_001195433 NP_001182362 NM_001195434 NP_001182363 NM_022443 NP_071888 |
| Function | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:15861129}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=In non- hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM. |
| Tissue Specificity | Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes. |
| Top Pathways | Transcriptional misregulation in cancer |