OLIG2
| Gene Symbol | OLIG2 |
|---|---|
| Entrez Gene | 10215 |
| Alt Symbol | BHLHB1, OLIGO2, PRKCBP2, RACK17, bHLHe19 |
| Species | Human |
| Gene Type | protein-coding |
| Description | oligodendrocyte lineage transcription factor 2 |
| Other Description | basic domain, helix-loop-helix protein, class B, 1|class B basic helix-loop-helix protein 1|class E basic helix-loop-helix protein 19|human protein kinase C-binding protein RACK17|oligodendrocyte transcription factor 2|oligodendrocyte-specific bHLH transcription factor 2|protein kinase C-binding protein 2 |
| Swissprots | Q05BP9 Q49AL3 Q86X04 B3KRF3 Q9NZ14 Q13516 |
| Accessions | EAX09851 Q13516 AF221520 AAF61215 AK091462 BAG52365 AU130620 BC034681 AAH34681 BC036245 AAH36245 BC036275 BC047511 AAH47511 DA500051 R42179 U48250 AAC72247 XM_005260908 XP_005260965 NM_005806 NP_005797 |
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. {ECO:0000250}. |
| Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. {ECO:0000269|PubMed:11498220, ECO:0000269|PubMed:11526205}. |
OLIG2 CRISPR/Cas9 KO Plasmid (h) - sc-400670 from Santa Cruz Biotechnology
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OLIG2 HDR Plasmid (h) - sc-400670-HDR from Santa Cruz Biotechnology
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OLIG2 Double Nickase Plasmid (h) - sc-400670-NIC from Santa Cruz Biotechnology
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OLIG2 Double Nickase Plasmid (h2) - sc-400670-NIC-2 from Santa Cruz Biotechnology
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OLIG2 CRISPR Activation Plasmid (h) - sc-400670-ACT from Santa Cruz Biotechnology
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OLIG2 CRISPR Activation Plasmid (h2) - sc-400670-ACT-2 from Santa Cruz Biotechnology
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OLIG2 Lentiviral Activation Particles (h) - sc-400670-LAC from Santa Cruz Biotechnology
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OLIG2 Lentiviral Activation Particles (h2) - sc-400670-LAC-2 from Santa Cruz Biotechnology
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OLIG2 siRNA (h) - sc-38147 from Santa Cruz Biotechnology
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OLIG2 shRNA Plasmid (h) - sc-38147-SH from Santa Cruz Biotechnology
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OLIG2 shRNA (h) Lentiviral Particles - sc-38147-V from Santa Cruz Biotechnology
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Olig2 RNAi - H00010215-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN15723 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15723 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09131 from Sigma-Aldrich
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OLIG2 siRNA (Human) - CRH6904 from Cohesion Biosciences
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OLIG2 CRISPR/Cas9 KO Plasmid (h2) - sc-400670-KO-2 from Santa Cruz Biotechnology
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OLIG2 HDR Plasmid (h2) - sc-400670-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human OLIG2 (NM_005806.3) - SHH361644 from Creative biogene
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OLIG2 shRNA Plasmid (Human) - CHH6904 from Cohesion Biosciences
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OLIG2 miRNA 3'UTR clone - MiUTR3H-08413 from Creative biogene
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