OLIG2

Gene Symbol OLIG2
Entrez Gene 10215
Alt Symbol BHLHB1, OLIGO2, PRKCBP2, RACK17, bHLHe19
Species Human
Gene Type protein-coding
Description oligodendrocyte lineage transcription factor 2
Other Description basic domain, helix-loop-helix protein, class B, 1|class B basic helix-loop-helix protein 1|class E basic helix-loop-helix protein 19|human protein kinase C-binding protein RACK17|oligodendrocyte transcription factor 2|oligodendrocyte-specific bHLH transcription factor 2|protein kinase C-binding protein 2
Swissprots Q05BP9 Q49AL3 Q86X04 B3KRF3 Q9NZ14 Q13516
Accessions EAX09851 Q13516 AF221520 AAF61215 AK091462 BAG52365 AU130620 BC034681 AAH34681 BC036245 AAH36245 BC036275 BC047511 AAH47511 DA500051 R42179 U48250 AAC72247 XM_005260908 XP_005260965 NM_005806 NP_005797
Function Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. {ECO:0000250}.
Tissue Specificity Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. {ECO:0000269|PubMed:11498220, ECO:0000269|PubMed:11526205}.

OLIG2 (H-68) - sc-48817 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
OLIG2 (H-68): sc-48817. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

OLIG2 (C-17) - sc-19969 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OLIG2 (C-17): sc-19969. Western blot analysis of OLIG2 expression in Jurkat (A) and Hep G2 (B) whole cell lysates and rat brain (C) and mouse brain (D) tissue extracts.

OLIG2 (N-17) - sc-19967 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OLIG2 (X-24) - sc-133869 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
OLIG2 (X-24): sc-133869. Western blot analysis of OLIG2 expression in Jurkat whole cell lysate.

Anti-Olig2 antibody - ab85900 from Abcam

Prices $378.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal
ICC/IF image of ab85900 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab85900, 1/100 dilution) overnight at +4°C. The secondary antibody (green) was ab96939, DyLight® 488 donkey anti-sheep IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Olig2 antibody - ab187740 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Olig2 antibody (ab187740) at 1/500 dilution + FOA 1 cell lysate

Anti-Olig2 antibody - ab56643 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Standard Curve for Olig2; dilution range 1 pg/ml to 1 ug/ml using Capture Antibody Mouse monoclonal to Olig2 (ab56643) at 5 ug/ml and Detector Antibody Rabbit polyclonal to Olig2 (ab77953) at 0.5 ug/ml.

Anti-Olig2 antibody - ab136253 from Abcam

Prices $359.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of glioblastoma labelling Olig2 with ab136253 at 1/500 dilution. Tissue was pretreated with TE Buffer, pH 9.0.

Anti-Olig2 antibody [1G11] - ab110031 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G11
All lanes : Anti-Olig2 antibody [1G11] (ab110031) at 1/500 dilutionLane 1 : HEK 293 cell lysateLane 2 : Olig2-hIgGFc transfected HEK 293 cell lysate

Anti-Olig2 antibody [3C9] - ab124398 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3C9
Staining of Olig2 in Paraffin-embedded Human Brain, Oligodendroglia tissue by Immunohistochemistry using ab124398 at a concentration of 5 µg/ml.

Anti-Olig2 antibody [EPR2673] - ab109186 from Abcam

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2673
All lanes : Anti-Olig2 antibody [EPR2673] (ab109186) at 1/2000 dilution (purified)Lane 1 : Mouse brain lysateLane 2 : Mouse brain lysateLysates/proteins at 20 µg per lane.SecondaryHRP goat anti-rabbit (H+L) at 1/1000 dilution

Anti-OLIG2 Antibody (aa236-285) IHC-plus™ - LS-B1552 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-OLIG2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1552 concentration 5 ug/ml.

Anti-OLIG2 Antibody (clone 1G11) - LS-C169317 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G11
IHC of paraffin-embedded muscle tissues using OLIG2 mouse monoclonal antibody with DAB staining.

Anti-OLIG2 Antibody (N-Terminus) - LS-C336155 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of OLIG2 in rat brain tissue with OLIG2 antibody at 5 ug/mL.

Anti-OLIG2 Antibody (N-Terminus) - LS-C94372 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-OLIG2 Antibody - LS-C124309 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OLIG2 Antibody (N-Terminus) - LS-C136273 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-OLIG2 Antibody (C-Terminus) - LS-C144915 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OLIG2 Antibody (phospho-Ser147) - LS-C145184 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OLIG2 Antibody (C-Terminus) - LS-C153401 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OLIG2 Antibody - LS-C194022 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OLIG2 Antibody (aa50-100) - LS-C203179 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-OLIG2 Antibody (C-Terminus) - LS-C209974 from LifeSpan Bioscience

Prices $405.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-OLIG2 Antibody (aa152-180, AP) - LS-C216168 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OLIG2 Antibody (aa152-180, APC) - LS-C216169 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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