SENP1

Gene Symbol SENP1
Entrez Gene 29843
Alt Symbol SuPr-2
Species Human
Gene Type protein-coding
Description SUMO1/sentrin specific peptidase 1
Other Description SUMO1/sentrin specific protease 1|sentrin-specific protease 1|sentrin/SUMO-specific protease SENP1
Swissprots Q86XC8 A8K7P5 Q9P0U3
Accessions EAW57971 EAW57972 Q9P0U3 AF149770 AAF31171 AK292060 BAF84749 AK312874 AL582855 BC045639 AAH45639 BI560893 BX537920 CAD97903 BX640784 CAE45874 XM_006719361 XP_006719424 XM_006719362 XP_006719425 XM_011538244 XP_011536546 XM_011538245 XP_011536547 NM_001267594 NP_001254523 NM_001267595 NP_001254524 NR_051991 NR_051992 NM_014554
Function Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374}.
Subcellular Location Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
Tissue Specificity Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine. {ECO:0000269|PubMed:15487983}.

SENP1 (D16D7) Rabbit mAb - 11929 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D16D7
Western blot analysis of extracts from 293, A-204, and PANC-1 cells using SENP1 (D16D7) Rabbit mAb.

SENP1 (C-12) - sc-271360 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SENP1 (C-12): sc-271360. Western blot analysis of SENP1 expression in K-562 (A) and HEK293 (B) whole cell lysates.

SENP1 (H-65) - sc-67074 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SENP1 (H-65): sc-67074. Immunoperoxidase staining of formalin fixed, paraffin-embedded human vagina tissue showing cytoplasmic and nuclear staining of squamous epithelial cells.

SENP1 (Y-20) - sc-46634 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SENP1 antibody - ab58417 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human breast carcinoma tissue using ab58417 at 1/50 dilution. Samples are treated -/+ blocking peptide.

Anti-SENP1 antibody - ab3656 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis SENP 1 in whole HL60 cell lysate. SENP1 (Arrow) was detected using ab3656 (Lane B) but not pre-immune serum (lane A). Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Anti-SENP1 antibody - ab3657 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of SENP 1 in whole HL60 cell lysate using ab3657 (Lane B) but not pre-immune serum (lane A). Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Anti-SENP1 antibody - ab83321 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SENP1 antibody (ab83321) at 1 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SENP1 antibody - ab169019 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-SENP1 antibody (ab169019) at 1 µg/mlLane 1 : SENP1 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-SENP1 antibody - ab103523 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SENP1 antibody [EPR3844] - ab108981 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3844
All lanes : Anti-SENP1 antibody [EPR3844] (ab108981) at 1/1000 dilutionLane 1 : HeLa cell lysates Lane 2 : HUVEC cell lysates Lane 3 : Jurkat cell lysates Lane 4 : Daudi cell lysatesLane 5 : U87-MG cell lysates Lysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SENP1 antibody [EPR3844] (Alexa Fluor® 488) - ab201543 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3844
ab201543 staining SENP1 in HeLa cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab201543 at a 1/100 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at a 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in HeLa cells fixed with 100% methanol (5 min).

Anti-SENP1 antibody [EPR3844] (Alexa Fluor® 647) - ab201261 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3844
ab201261 staining SENP1 in HeLa cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab201261 at a 1/100 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at a 1/250 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-SENP1 Antibody (aa262-290) - LS-C324998 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP1 Antibody (clone 1D7) - LS-C175077 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D7
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SENP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SENP1.

Anti-SENP1 Antibody (N-Terminus) - LS-C328614 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP1 Antibody (C-Terminus) - LS-C328615 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP1 Antibody (C-Terminus) IHC-plus™ - LS-B5861 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SENP1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5861 concentration 5 ug/ml.

Anti-SENP1 Antibody (aa28-59) IHC-plus™ - LS-B3387 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-SENP1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3387 concentration 10 ug/ml.

Anti-SENP1 Antibody (aa1-50) IHC-plus™ - LS-B7649 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SENP1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7649 concentration 10 ug/ml.

Anti-SENP1 Antibody (aa189-206) - LS-C3187 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SENP1 Antibody - LS-C10080 from LifeSpan Bioscience

Prices $445.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP1 Antibody (aa578-590) - LS-C792 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SENP1 in 15 ugs of (A) Jurkat and (B) NIH3T3 cell lysate using antibody at 1:1000.

Anti-SENP1 Antibody (aa262-289, AP) - LS-C240555 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP1 Antibody (aa262-289, Biotin) - LS-C240556 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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