| Gene Symbol |
SENP1
|
| Entrez Gene |
29843
|
| Alt Symbol |
SuPr-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SUMO1/sentrin specific peptidase 1
|
| Other Description |
SUMO1/sentrin specific protease 1|sentrin-specific protease 1|sentrin/SUMO-specific protease SENP1
|
| Swissprots |
Q86XC8 A8K7P5 Q9P0U3
|
| Accessions |
EAW57971 EAW57972 Q9P0U3 AF149770 AAF31171 AK292060 BAF84749 AK312874 AL582855 BC045639 AAH45639 BI560893 BX537920 CAD97903 BX640784 CAE45874 XM_006719361 XP_006719424 XM_006719362 XP_006719425 XM_011538244 XP_011536546 XM_011538245 XP_011536547 NM_001267594 NP_001254523 NM_001267595 NP_001254524 NR_051991 NR_051992 NM_014554
|
| Function |
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
|
| Tissue Specificity |
Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine. {ECO:0000269|PubMed:15487983}.
|