| Gene Symbol |
LMAN2
|
| Entrez Gene |
10960
|
| Alt Symbol |
C5orf8, GP36B, VIP36
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lectin, mannose-binding 2
|
| Other Description |
glycoprotein GP36b|vesicular integral protein of 36 kDa|vesicular integral-membrane protein 36|vesicular integral-membrane protein VIP36
|
| Swissprots |
Q53HH1 Q12907
|
| Accessions |
EAW85014 EAW85015 Q12907 AK222609 BAD96329 AK292099 BAF84788 AK301607 BAG63093 AK308027 BC017263 AAH17263 DC404202 JF432530 ADZ15747 U10362 AAA19572 NM_006816 NP_006807
|
| Function |
Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269|PubMed:10444376}. Golgi apparatus membrane {ECO:0000269|PubMed:10444376}; Single-pass membrane protein {ECO:0000269|PubMed:10444376}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269|PubMed:10444376}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|
![Western Blot: LMAN2 Overexpression Lysate (Adult Normal) [NBP2-07575] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LMAN2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10153_LMAN2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07575-img0001.jpg)