Gene Symbol | LMAN2 |
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Entrez Gene | 10960 |
Alt Symbol | C5orf8, GP36B, VIP36 |
Species | Human |
Gene Type | protein-coding |
Description | lectin, mannose-binding 2 |
Other Description | glycoprotein GP36b|vesicular integral protein of 36 kDa|vesicular integral-membrane protein 36|vesicular integral-membrane protein VIP36 |
Swissprots | Q53HH1 Q12907 |
Accessions | EAW85014 EAW85015 Q12907 AK222609 BAD96329 AK292099 BAF84788 AK301607 BAG63093 AK308027 BC017263 AAH17263 DC404202 JF432530 ADZ15747 U10362 AAA19572 NM_006816 NP_006807 |
Function | Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269|PubMed:10444376}. Golgi apparatus membrane {ECO:0000269|PubMed:10444376}; Single-pass membrane protein {ECO:0000269|PubMed:10444376}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269|PubMed:10444376}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Protein processing in endoplasmic reticulum |
VIP36 CRISPR/Cas9 KO Plasmid (h) - sc-407021 from Santa Cruz Biotechnology
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VIP36 HDR Plasmid (h) - sc-407021-HDR from Santa Cruz Biotechnology
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VIP36 Double Nickase Plasmid (h) - sc-407021-NIC from Santa Cruz Biotechnology
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VIP36 Double Nickase Plasmid (h2) - sc-407021-NIC-2 from Santa Cruz Biotechnology
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VIP36 CRISPR Activation Plasmid (h) - sc-407021-ACT from Santa Cruz Biotechnology
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VIP36 CRISPR Activation Plasmid (h2) - sc-407021-ACT-2 from Santa Cruz Biotechnology
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VIP36 Lentiviral Activation Particles (h) - sc-407021-LAC from Santa Cruz Biotechnology
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VIP36 Lentiviral Activation Particles (h2) - sc-407021-LAC-2 from Santa Cruz Biotechnology
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VIP36 siRNA (h) - sc-45242 from Santa Cruz Biotechnology
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VIP36 shRNA Plasmid (h) - sc-45242-SH from Santa Cruz Biotechnology
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VIP36 shRNA (h) Lentiviral Particles - sc-45242-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU045781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11761 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02681 from Sigma-Aldrich
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LMAN2 siRNA (Human) - CRH7481 from Cohesion Biosciences
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LMAN2 RNAi - H00010960-R01 from Novus Biologicals
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shRNA set against Human LMAN2 (NM_006816.2) - SHH330883 from Creative biogene
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shRNA set against Human LMAN2(NM_006816.2) - SHH151643 from Creative biogene
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LMAN2 shRNA Plasmid (Human) - CHH7481 from Cohesion Biosciences
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LMAN2 miRNA 3'UTR clone - MiUTR1H-05709 from Creative biogene
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