LARGE

Gene Symbol	LARGE
Entrez Gene	9215
Alt Symbol	MDC1D, MDDGA6, MDDGB6
Species	Human
Gene Type	protein-coding
Description	like-glycosyltransferase
Other Description	acetylglucosaminyltransferase-like 1A|acetylglucosaminyltransferase-like protein|glycosyltransferase-like protein LARGE1
Swissprots	Q17R80 Q9UGG3 Q9UGE7 O95461 B0QXZ7 Q9UGD1 Q9UH22 O60348 Q9UGZ8
Accessions	CAI17890 CAQ09433 CAQ09434 CAQ09435 CAX15214 CAX15215 EAW60041 EAW60042 EAW60043 O95461 AB011181 BAA25535 AI167885 AI198348 AI199197 AJ007583 CAA07571 AK294766 BAH11875 AK295636 BAH12135 AK301808 BAH13559 AK310462 BC117425 AAI17426 BC126404 AAI26405 BF057493 CR456510 CAG30396 CU013109 CAK54540 CU013397 CAK54839 DR000293 HQ258512 ADR83266 KJ534877 AHW56517 KJ535033 AHW56672 KJ535073 AHW56712 KJ535074 AHW56713 XM_005261831 XP_005261888 XM_005261832 XP_005261889 XM_011530510 XP_011528812 XM_011530511 XP_011528813 XM_011530512 XP_011528814 XM_011530513 XP_011528815 XM_011530514 XP_011528816 NM_004737 NP_004728 NM_133642 NP_598397
Function	Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699). {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15752776, ECO:0000269|PubMed:21987822, ECO:0000269|PubMed:22223806, ECO:0000269|PubMed:25138275, ECO:0000269|PubMed:25279697, ECO:0000269|PubMed:25279699}.
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15958417, ECO:0000269|PubMed:25279699}; Single-pass type II membrane protein {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15958417}.
Tissue Specificity	Ubiquitous. Highest expression in heart, brain and skeletal muscle. {ECO:0000269|PubMed:15752776}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LARGE full length protein - ab160387 from Abcam Category Protein Source Wheat germ Species Human

LARGE Antibody Blocking Peptide - LS-E27334 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LARGE Antibody Blocking Peptide - LS-E27335 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LARGE Antibody Blocking Peptide - LS-E16945 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LARGE Protein - H00009215-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

LARGE (aa421-433) blocking peptide - GTX88124-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

LARGE (N-terminus) blocking peptide - GTX88123-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

LARGE Blocking Peptide - 33R-1247 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LARGE Peptide - AC21-2158-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

LARGE Peptide - AC21-2159-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

LARGE - H00009215-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

LARGE Peptide - 42-561P from ProSci Category Peptide

LARGE Peptide - 42-560P from ProSci Category Peptide Species Human

LARGE fusion protein - ag19470 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

LARGE fusion protein - ag19458 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human LARGE - LARGE-653H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Like Glycosyltransferase (LARGE) - RPH936Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Like Glycosyltransferase (LARGE) - RPH936Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Glycosyltransferase-like protein LARGE1(LARGE) - CSB-YP012749HU CSB-EP012749HU CSB-BP012749HU CSB-MP012749HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LARGE, Peptide - MBS428474 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Bovine

LARGE, Peptide - MBS427263 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Bovine

LARGE Protein - NBP1-82983PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

LARGE-Blocking-Peptide-Center - BP21980c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LARGE Peptide, Human - M34GP08547H from Creative Peptides Category Peptide Source Synthetic. Species Human

LARGE Recombinant Protein (OPCD04841) - OPCD04841 from Aviva Systems Biology Category Protein Source E.coli Species Human

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