LARGE

Gene Symbol LARGE
Entrez Gene 9215
Alt Symbol MDC1D, MDDGA6, MDDGB6
Species Human
Gene Type protein-coding
Description like-glycosyltransferase
Other Description acetylglucosaminyltransferase-like 1A|acetylglucosaminyltransferase-like protein|glycosyltransferase-like protein LARGE1
Swissprots Q17R80 Q9UGG3 Q9UGE7 O95461 B0QXZ7 Q9UGD1 Q9UH22 O60348 Q9UGZ8
Accessions CAI17890 CAQ09433 CAQ09434 CAQ09435 CAX15214 CAX15215 EAW60041 EAW60042 EAW60043 O95461 AB011181 BAA25535 AI167885 AI198348 AI199197 AJ007583 CAA07571 AK294766 BAH11875 AK295636 BAH12135 AK301808 BAH13559 AK310462 BC117425 AAI17426 BC126404 AAI26405 BF057493 CR456510 CAG30396 CU013109 CAK54540 CU013397 CAK54839 DR000293 HQ258512 ADR83266 KJ534877 AHW56517 KJ535033 AHW56672 KJ535073 AHW56712 KJ535074 AHW56713 XM_005261831 XP_005261888 XM_005261832 XP_005261889 XM_011530510 XP_011528812 XM_011530511 XP_011528813 XM_011530512 XP_011528814 XM_011530513 XP_011528815 XM_011530514 XP_011528816 NM_004737 NP_004728 NM_133642 NP_598397
Function Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699). {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15752776, ECO:0000269|PubMed:21987822, ECO:0000269|PubMed:22223806, ECO:0000269|PubMed:25138275, ECO:0000269|PubMed:25279697, ECO:0000269|PubMed:25279699}.
Subcellular Location Golgi apparatus membrane {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15958417, ECO:0000269|PubMed:25279699}; Single-pass type II membrane protein {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15958417}.
Tissue Specificity Ubiquitous. Highest expression in heart, brain and skeletal muscle. {ECO:0000269|PubMed:15752776}.

LARGE CRISPR/Cas9 KO Plasmid (h) - sc-405490 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LARGE HDR Plasmid (h) - sc-405490-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LARGE Double Nickase Plasmid (h) - sc-405490-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LARGE Double Nickase Plasmid (h2) - sc-405490-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LARGE CRISPR Activation Plasmid (h) - sc-405490-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LARGE CRISPR Activation Plasmid (h2) - sc-405490-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LARGE Lentiviral Activation Particles (h) - sc-405490-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LARGE Lentiviral Activation Particles (h2) - sc-405490-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LARGE siRNA (h) - sc-44965 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LARGE shRNA Plasmid (h) - sc-44965-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LARGE shRNA (h) Lentiviral Particles - sc-44965-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU079301 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11549 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11549 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LARGE siRNA (Human) - CRH6100 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LARGE (NM_004737.4) - SHH328487 from Creative biogene

Category siRNA
Species Reactivities Human

Human LARGE siRNA - orb266602 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LARGE shRNA Plasmid (Human) - CHH6100 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LARGE miRNA 3'UTR clone - MiUTR3H-06095 from Creative biogene

Species Reactivities Human

LARGE miRNA 3'UTR clone - MiUTR3H-06096 from Creative biogene

Species Reactivities Human
Search more