| Gene Symbol |
ZEB1
|
| Entrez Gene |
6935
|
| Alt Symbol |
AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger E-box binding homeobox 1
|
| Other Description |
delta-crystallin enhancer binding factor 1|negative regulator of IL2|posterior polymorphous corneal dystrophy 3|transcription factor 8 (represses interleukin 2 expression)|zinc finger E-box-binding homeobox 1|zinc finger homeodomain enhancer-binding protein
|
| Swissprots |
F5H4I8 E9PCM7 P37275 Q5T968 Q13800 Q8NB68 B4DJV0 Q12924 Q2KJ05 Q5VZ84 B4DUW9
|
| Accessions |
CCO13853 CCQ43736 EAW85989 EAW85990 P37275 AI086650 AK091478 BAC03673 AK294775 BAG57903 AK296244 BAG58962 AK299541 BAG61488 AK299666 BAG61580 AK300830 BAG62481 AK307510 AK308785 AK308822 AK309331 AK309399 AK310924 AK311116 AK311137 AK311187 AK311201 AK311372 AK311557 AK314683 BAG37235 AL831979 BC009572 AAH09572 BC065705 BC107781 AAI07782 BC112392 AAI12393 BQ003893 BX111519 BX647794 DB442432 DC299346 M81699 U12170 AAA20602 XM_005252576 XP_005252633 XM_006717497 XP_006717560 XM_006717498 XP_006717561 XM_011519641 XP_011517943 XM_011519642 XP_011517944 XM_011519643 XP_011517945 XM_011519644 XP_011517946 XM_011519645 XP_011517947 XM_011519646 XP_011517948 XM_011519647 XP_011517949 XM_011519648 XP_011517950 NM_001128128 NP_001121600 NM_001174093 NP_001167564 NM_001174094 NP_001167565 NM_001174095 NP_001167566 NM_001174096 NP_001167567 NM_030751 NP_110378 NR_024285 NR_024286 NR_024287
|
| Function |
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. {ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20418909}.
|
| Tissue Specificity |
Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. {ECO:0000269|PubMed:20418909}.
|
| Top Pathways |
MicroRNAs in cancer, Transcriptional misregulation in cancer
|