ZEB1

Gene Symbol	ZEB1
Entrez Gene	6935
Alt Symbol	AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Species	Human
Gene Type	protein-coding
Description	zinc finger E-box binding homeobox 1
Other Description	delta-crystallin enhancer binding factor 1|negative regulator of IL2|posterior polymorphous corneal dystrophy 3|transcription factor 8 (represses interleukin 2 expression)|zinc finger E-box-binding homeobox 1|zinc finger homeodomain enhancer-binding protein
Swissprots	F5H4I8 E9PCM7 P37275 Q5T968 Q13800 Q8NB68 B4DJV0 Q12924 Q2KJ05 Q5VZ84 B4DUW9
Accessions	CCO13853 CCQ43736 EAW85989 EAW85990 P37275 AI086650 AK091478 BAC03673 AK294775 BAG57903 AK296244 BAG58962 AK299541 BAG61488 AK299666 BAG61580 AK300830 BAG62481 AK307510 AK308785 AK308822 AK309331 AK309399 AK310924 AK311116 AK311137 AK311187 AK311201 AK311372 AK311557 AK314683 BAG37235 AL831979 BC009572 AAH09572 BC065705 BC107781 AAI07782 BC112392 AAI12393 BQ003893 BX111519 BX647794 DB442432 DC299346 M81699 U12170 AAA20602 XM_005252576 XP_005252633 XM_006717497 XP_006717560 XM_006717498 XP_006717561 XM_011519641 XP_011517943 XM_011519642 XP_011517944 XM_011519643 XP_011517945 XM_011519644 XP_011517946 XM_011519645 XP_011517947 XM_011519646 XP_011517948 XM_011519647 XP_011517949 XM_011519648 XP_011517950 NM_001128128 NP_001121600 NM_001174093 NP_001167564 NM_001174094 NP_001167565 NM_001174095 NP_001167566 NM_001174096 NP_001167567 NM_030751 NP_110378 NR_024285 NR_024286 NR_024287
Function	Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. {ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:20418909}.
Tissue Specificity	Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. {ECO:0000269|PubMed:20418909}.
Top Pathways	MicroRNAs in cancer, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AREB6 peptide - ab66485 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human AREB6 protein fragment - ab152728 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ZEB1 / AREB6 Antibody Blocking Peptide - LS-E25155 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZEB1 / AREB6 Antibody Blocking Peptide - LS-E30954 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ZEB1 / AREB6 Antibody Blocking Peptide - LS-E26980 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZEB1 Partial Recombinant Protein - H00006935-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ZEB1 Blocking Peptide - NBP1-77178PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

ZEB1 blocking peptide - GTX88467-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Goat anti ZEB1 antibody Immunizing peptide - orb17280 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

AREB6 Peptide - AC21-1806-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ZEB1 - H00006935-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ZEB1 - H00006935-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ZEB1 Peptide - 46-932P from ProSci Category Peptide Species Human, Mouse

ZEB1 Peptide - 5825P from ProSci Category Peptide Species Human

ZEB1 fusion protein - Ag16204 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

ZEB1 fusion protein - ag17118 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ZEB1, GST-tagged - ZEB1-3796H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Zinc finger E-box-binding homeobox 1(ZEB1) ,partial - CSB-YP026424HU CSB-EP026424HU CSB-BP026424HU CSB-MP026424HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Zinc finger E-box-binding homeobox 1(ZEB1) ,partial, Recombinant Protein - MBS956450 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Zinc Finger E-box Binding Homeobox 1, Peptide - MBS659750 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg Species Human, Rat

AREB6/ZEB1, Peptide - MBS425875 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

ZEB1 Recombinant Protein Antigen - NBP1-88845PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ZEB1 Peptide, Human - M34GP17770H from Creative Peptides Category Peptide Source Synthetic. Species Human

ZEB1 Recombinant Protein Antigen - NBP2-52866PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E. coli Species Human

Recombinant Human ZEB1 Protein, GST-tagged - ZEB1-22H from Creative Biomart Category Protein Source Wheat Germ Species Human

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