| Gene Symbol |
POSTN
|
| Entrez Gene |
10631
|
| Alt Symbol |
OSF-2, OSF2, PDLPOSTN, PN, periostin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
periostin, osteoblast specific factor
|
| Other Description |
osteoblast specific factor 2 (fasciclin I-like)|periodontal ligament-specific periostin|periostin
|
| Swissprots |
Q5VSY5 Q15064 C0IMJ4 C0IMJ1 B1ALD8 Q8IZF9 Q15063 F5H628 D2KRH7 Q3KPJ5 Q29XZ0 C0IMJ2
|
| Accessions |
EAX08590 EAX08591 EAX08592 EAX08593 EAX08594 Q15063 AI580215 AK021444 AK297914 BAH12690 AK300261 BAH13247 AK304640 BAG65419 AY140646 AAN17733 AY918092 AAY15840 BC106709 AAI06710 BC106710 AAI06711 BG938993 BP335818 BQ575951 BY795054 D13665 BAA02836 D13666 BAA02837 DC403736 EU262883 ABY86630 EU262884 ABY86631 EU262885 ABY86632 EU262886 ABY86633 GU354210 ADA79517 XM_005266231 XP_005266288 XM_005266232 XP_005266289 NM_001135934 NP_001129406 NM_001135935 NP_001129407 NM_001135936 NP_001129408 NM_001286665 NP_001273594 NM_001286666 NP_001273595 NM_001286667 NP_001273596 NM_006475 NP_006466
|
| Function |
Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. {ECO:0000250, ECO:0000269|PubMed:12235007, ECO:0000269|PubMed:18450759}.
|
| Subcellular Location |
Golgi apparatus {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12235007}. Note=Colocalizes with BMP1 in the Golgi. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers. {ECO:0000269|PubMed:11550156, ECO:0000269|PubMed:12235007, ECO:0000269|PubMed:15082792, ECO:0000269|PubMed:23946676}.
|