| Gene Symbol |
Inmt
|
| Entrez Gene |
21743
|
| Alt Symbol |
Temt
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
indolethylamine N-methyltransferase
|
| Other Description |
amine N-methyltransferase|aromatic alkylamine N-methyltransferase|arylamine N-methyltransferase|indolamine N-methyltransferase|nicotine N-methyltransferase|thioether S-methyltransferase
|
| Swissprots |
Q9CZ50 P40936
|
| Accessions |
EDK98722 EDK98723 EDK98724 P40936 AK002281 BAB21985 AK013010 BAB28594 BC013518 AAH13518 M88694 AAA62365 NM_009349 NP_033375
|
| Function |
Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n- propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. {ECO:0000250, ECO:0000269|PubMed:3350800}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:3350800}.
|
| Tissue Specificity |
Detected in lung and liver (at protein level). {ECO:0000269|PubMed:3350800}.
|
| Top Pathways |
Selenocompound metabolism, Tryptophan metabolism
|