Gene Symbol | Inmt |
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Entrez Gene | 21743 |
Alt Symbol | Temt |
Species | Mouse |
Gene Type | protein-coding |
Description | indolethylamine N-methyltransferase |
Other Description | amine N-methyltransferase|aromatic alkylamine N-methyltransferase|arylamine N-methyltransferase|indolamine N-methyltransferase|nicotine N-methyltransferase|thioether S-methyltransferase |
Swissprots | Q9CZ50 P40936 |
Accessions | EDK98722 EDK98723 EDK98724 P40936 AK002281 BAB21985 AK013010 BAB28594 BC013518 AAH13518 M88694 AAA62365 NM_009349 NP_033375 |
Function | Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n- propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. {ECO:0000250, ECO:0000269|PubMed:3350800}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:3350800}. |
Tissue Specificity | Detected in lung and liver (at protein level). {ECO:0000269|PubMed:3350800}. |
Top Pathways | Selenocompound metabolism, Tryptophan metabolism |
INMT CRISPR/Cas9 KO Plasmid (m) - sc-423336 from Santa Cruz Biotechnology
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INMT HDR Plasmid (m) - sc-423336-HDR from Santa Cruz Biotechnology
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INMT Double Nickase Plasmid (m) - sc-423336-NIC from Santa Cruz Biotechnology
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INMT Double Nickase Plasmid (m2) - sc-423336-NIC-2 from Santa Cruz Biotechnology
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INMT CRISPR Activation Plasmid (m) - sc-423336-ACT from Santa Cruz Biotechnology
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INMT CRISPR Activation Plasmid (m2) - sc-423336-ACT-2 from Santa Cruz Biotechnology
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INMT Lentiviral Activation Particles (m) - sc-423336-LAC from Santa Cruz Biotechnology
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INMT Lentiviral Activation Particles (m2) - sc-423336-LAC-2 from Santa Cruz Biotechnology
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INMT siRNA (m) - sc-146238 from Santa Cruz Biotechnology
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INMT shRNA Plasmid (m) - sc-146238-SH from Santa Cruz Biotechnology
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INMT shRNA (m) Lentiviral Particles - sc-146238-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU012201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33848 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33848 from Sigma-Aldrich
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INMT siRNA (Mouse) - CRM4088 from Cohesion Biosciences
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INMT - MBS8210275 from MyBioSource
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shRNA set against Mouse INMT (NM_009349.3) - SHH319593 from Creative biogene
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shRNA set against Mouse Inmt(NM_009349.3) - SHL178226 from Creative biogene
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INMT shRNA Plasmid (Mouse) - CHM4088 from Cohesion Biosciences
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INMT miRNA 3'UTR clone - MiUTR1M-06054 from Creative biogene
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