| Gene Symbol |
RAB11FIP2
|
| Entrez Gene |
22841
|
| Alt Symbol |
Rab11-FIP2, nRip11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB11 family interacting protein 2 (class I)
|
| Other Description |
RAB11-FIP2 long isoform|rab11 family-interacting protein 2
|
| Swissprots |
A6NEI4 Q3I768 Q9Y2F0 Q7L804
|
| Accessions |
EAW49423 Q7L804 AB023158 BAA76785 AY037299 AAK68635 BC075073 AAH75073 BC075074 AAH75074 BM975322 BX647717 DQ013303 AAY67796 XM_005269629 XP_005269686 XM_011539511 XP_011537813 XM_011539512 XP_011537814 XM_011539513 XP_011537815 NM_014904 NP_055719
|
| Function |
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231}.
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
|
| Top Pathways |
Endocytosis
|