Gene Symbol | RAB11FIP2 |
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Entrez Gene | 22841 |
Alt Symbol | Rab11-FIP2, nRip11 |
Species | Human |
Gene Type | protein-coding |
Description | RAB11 family interacting protein 2 (class I) |
Other Description | RAB11-FIP2 long isoform|rab11 family-interacting protein 2 |
Swissprots | A6NEI4 Q3I768 Q9Y2F0 Q7L804 |
Accessions | EAW49423 Q7L804 AB023158 BAA76785 AY037299 AAK68635 BC075073 AAH75073 BC075074 AAH75074 BM975322 BX647717 DQ013303 AAY67796 XM_005269629 XP_005269686 XM_011539511 XP_011537813 XM_011539512 XP_011537814 XM_011539513 XP_011537815 NM_014904 NP_055719 |
Function | A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231}. |
Subcellular Location | Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. |
Top Pathways | Endocytosis |
Rab11-FIP2 (K-16) - sc-163273 from Santa Cruz Biotechnology
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Rab11-FIP2 (S-17) - sc-163274 from Santa Cruz Biotechnology
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Anti-RAB11-FIP2 antibody - ab76892 from Abcam
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Anti-RAB11-FIP2 antibody - ab174912 from Abcam
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Anti-RAB11-FIP2 antibody - ab104723 from Abcam
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Anti-RAB11-FIP2 antibody [EPR12294] - ab174313 from Abcam
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Anti-RAB11-FIP2 antibody [EPR12294-85] - ab180504 from Abcam
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa345-374, APC) - LS-C239668 from LifeSpan Bioscience
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa345-374, Biotin) - LS-C239669 from LifeSpan Bioscience
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa345-374, FITC) - LS-C239670 from LifeSpan Bioscience
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa322-371) - LS-C200548 from LifeSpan Bioscience
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa345-374, PE) - LS-C239671 from LifeSpan Bioscience
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa340-389) - LS-C120285 from LifeSpan Bioscience
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa345-374, Azide-free, HRP) - LS-C248598 from LifeSpan Bioscience
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa352-382) - LS-C324458 from LifeSpan Bioscience
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa71-120) - LS-C116602 from LifeSpan Bioscience
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa345-374, AP) - LS-C250009 from LifeSpan Bioscience
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Anti-RAB11FIP2 / Rab11-FIP2 Antibody (aa345-374) - LS-C162357 from LifeSpan Bioscience
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RAB11FIP2 Antibody - NBP1-57009 from Novus Biologicals
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RAB11FIP2 Antibody - NBP1-82949 from Novus Biologicals
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Anti-RAB11FIP2 antibody produced in rabbit - HPA037726 from Sigma-Aldrich
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Anti-RAB11FIP2, (N-terminal) antibody produced in rabbit - SAB2105953 from Sigma-Aldrich
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Anti-RAB11FIP2 antibody produced in rabbit - SAB4500899 from Sigma-Aldrich
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RAB11FIP2 antibody - N-terminal region (ARP55095_P050) - ARP55095_P050 from Aviva Systems Biology
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RAB11FIP2 Antibody - middle region (OAAB02889) - OAAB02889 from Aviva Systems Biology
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