| Gene Symbol |
THBS4
|
| Entrez Gene |
7060
|
| Alt Symbol |
TSP-4, TSP4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thrombospondin 4
|
| Other Description |
thrombospondin-4
|
| Swissprots |
P35443 Q86TG2 B2R909
|
| Accessions |
AAS66982 EAW95841 P35443 AK302842 BAH13818 AK313587 BAG36356 BC050456 AAH50456 DC310687 DC342285 DC376500 Z19585 CAA79635 XM_011543614 XP_011541916 NM_001306212 NP_001293141 NM_001306213 NP_001293142 NM_001306214 NP_001293143 NM_003248 NP_003239
|
| Function |
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By simi
|
| Subcellular Location |
Endoplasmic reticulum {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}. Secreted. Secreted, extracellular space {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
| Top Pathways |
Focal adhesion, ECM-receptor interaction, Phagosome, Malaria, PI3K-Akt signaling pathway
|