| Gene Symbol |
LANCL2
|
| Entrez Gene |
55915
|
| Alt Symbol |
GPR69B, TASP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LanC lantibiotic synthetase component C-like 2 (bacterial)
|
| Other Description |
G protein-coupled receptor 69B|LanC (bacterial lantibiotic synthetase component C)-like 2|lanC-like protein 2|testis-specific adriamycin sensitivity protein
|
| Swissprots |
Q6NSL4 Q8TCQ3 B2R8D4 Q9NS86 Q9BSR1
|
| Accessions |
AAQ93360 EAL23810 EAW50968 Q9NS86 AA994905 AB035966 BAA96800 AF353942 AAK83286 AJ278245 CAC21715 AK095857 BAG53147 AK225958 AK301747 BAG63209 AK307204 AK313326 BAG36131 AL713665 CAD28471 BC004887 AAH04887 BC070049 AAH70049 BF590020 BI869599 XM_011515448 XP_011513750 NM_018697 NP_061167
|
| Function |
Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. {ECO:0000269|PubMed:19667068}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Cell membrane. Note=Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta- cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo. Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin).
|
| Tissue Specificity |
Expressed in brain and testis. {ECO:0000269|PubMed:11762191}.
|