Gene Symbol | LANCL2 |
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Entrez Gene | 55915 |
Alt Symbol | GPR69B, TASP |
Species | Human |
Gene Type | protein-coding |
Description | LanC lantibiotic synthetase component C-like 2 (bacterial) |
Other Description | G protein-coupled receptor 69B|LanC (bacterial lantibiotic synthetase component C)-like 2|lanC-like protein 2|testis-specific adriamycin sensitivity protein |
Swissprots | Q6NSL4 Q8TCQ3 B2R8D4 Q9NS86 Q9BSR1 |
Accessions | AAQ93360 EAL23810 EAW50968 Q9NS86 AA994905 AB035966 BAA96800 AF353942 AAK83286 AJ278245 CAC21715 AK095857 BAG53147 AK225958 AK301747 BAG63209 AK307204 AK313326 BAG36131 AL713665 CAD28471 BC004887 AAH04887 BC070049 AAH70049 BF590020 BI869599 XM_011515448 XP_011513750 NM_018697 NP_061167 |
Function | Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. {ECO:0000269|PubMed:19667068}. |
Subcellular Location | Nucleus. Cytoplasm. Cell membrane. Note=Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta- cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo. Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin). |
Tissue Specificity | Expressed in brain and testis. {ECO:0000269|PubMed:11762191}. |
LANCL2 CRISPR/Cas9 KO Plasmid (h) - sc-410036 from Santa Cruz Biotechnology
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LANCL2 HDR Plasmid (h) - sc-410036-HDR from Santa Cruz Biotechnology
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LANCL2 Double Nickase Plasmid (h) - sc-410036-NIC from Santa Cruz Biotechnology
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LANCL2 Double Nickase Plasmid (h2) - sc-410036-NIC-2 from Santa Cruz Biotechnology
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LANCL2 CRISPR Activation Plasmid (h) - sc-410036-ACT from Santa Cruz Biotechnology
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LANCL2 CRISPR Activation Plasmid (h2) - sc-410036-ACT-2 from Santa Cruz Biotechnology
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LANCL2 Lentiviral Activation Particles (h) - sc-410036-LAC from Santa Cruz Biotechnology
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LANCL2 Lentiviral Activation Particles (h2) - sc-410036-LAC-2 from Santa Cruz Biotechnology
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LANCL2 siRNA (h) - sc-75407 from Santa Cruz Biotechnology
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LANCL2 shRNA Plasmid (h) - sc-75407-SH from Santa Cruz Biotechnology
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LANCL2 shRNA (h) Lentiviral Particles - sc-75407-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU024951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11543 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11543 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11495 from Sigma-Aldrich
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LANCL2 siRNA (Human) - CRJ1011 from Cohesion Biosciences
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shRNA set against Human LANCL2(NM_018697.3) - SHH142027 from Creative biogene
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Human LANCL2 siRNA - orb271512 from Biorbyt
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LANCL2 shRNA Plasmid (Human) - CHJ1011 from Cohesion Biosciences
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LANCL2 miRNA 3'UTR clone - MiUTR1H-05569 from Creative biogene
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