| Gene Symbol | SIGMAR1 |
|---|---|
| Entrez Gene | 10280 |
| Alt Symbol | ALS16, OPRS1, SIG-1R, SR-BP, SR-BP1, SRBP, hSigmaR1, sigma1R |
| Species | Human |
| Gene Type | protein-coding |
| Description | sigma non-opioid intracellular receptor 1 |
| Other Description | SR31747 binding protein 1|aging-associated gene 8 protein|sigma 1-type opioid receptor |
| Swissprots | Q0Z9W6 Q8N7H3 O00725 Q9NYX0 Q153Z1 Q7Z653 Q2TSD1 Q99720 O00673 D3DRM7 Q53GN2 |
| Accessions | AAC04507 EAW58431 EAW58434 EAW58435 EAW58436 EAW58437 Q99720 AF226604 AAF64280 AK098451 BAC05307 AK130502 AK222899 BAD96619 AK291092 BAF83781 AK299130 BAG61183 AY633611 AAV33304 BC004899 AAH04899 BC006307 BC007839 AAH07839 BC010104 BE018138 BI596428 CR457075 CAG33356 DQ644568 ABG29111 DQ647702 ABG36559 DQ656583 ABG46369 DQ892881 ABM83807 DQ896130 ABM87129 U75283 AAB50402 U79528 AAB51238 XM_011517674 XP_011515976 NM_001282205 NP_001269134 NM_001282206 NP_001269135 NM_001282207 NP_001269136 NM_001282208 NP_001269137 NM_001282209 NP_001269138 NM_005866 NP_005857 NM_147157 NP_671513 NR_104108 NM_147158 NM_147159 NM_147160 |
| Function | Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. {ECO:0000269|PubMed:16472803, ECO:0000269|PubMed:9341151}. |
| Subcellular Location | Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Note=Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand- binding. |
| Tissue Specificity | Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. {ECO:0000269|PubMed:11687279, ECO:0000269|PubMed:8954936, ECO:0000269|PubMed:9341151}. |