SIGMAR1

Gene Symbol SIGMAR1
Entrez Gene 10280
Alt Symbol ALS16, OPRS1, SIG-1R, SR-BP, SR-BP1, SRBP, hSigmaR1, sigma1R
Species Human
Gene Type protein-coding
Description sigma non-opioid intracellular receptor 1
Other Description SR31747 binding protein 1|aging-associated gene 8 protein|sigma 1-type opioid receptor
Swissprots Q0Z9W6 Q8N7H3 O00725 Q9NYX0 Q153Z1 Q7Z653 Q2TSD1 Q99720 O00673 D3DRM7 Q53GN2
Accessions AAC04507 EAW58431 EAW58434 EAW58435 EAW58436 EAW58437 Q99720 AF226604 AAF64280 AK098451 BAC05307 AK130502 AK222899 BAD96619 AK291092 BAF83781 AK299130 BAG61183 AY633611 AAV33304 BC004899 AAH04899 BC006307 BC007839 AAH07839 BC010104 BE018138 BI596428 CR457075 CAG33356 DQ644568 ABG29111 DQ647702 ABG36559 DQ656583 ABG46369 DQ892881 ABM83807 DQ896130 ABM87129 U75283 AAB50402 U79528 AAB51238 XM_011517674 XP_011515976 NM_001282205 NP_001269134 NM_001282206 NP_001269135 NM_001282207 NP_001269136 NM_001282208 NP_001269137 NM_001282209 NP_001269138 NM_005866 NP_005857 NM_147157 NP_671513 NR_104108 NM_147158 NM_147159 NM_147160
Function Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. {ECO:0000269|PubMed:16472803, ECO:0000269|PubMed:9341151}.
Subcellular Location Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Note=Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand- binding.
Tissue Specificity Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. {ECO:0000269|PubMed:11687279, ECO:0000269|PubMed:8954936, ECO:0000269|PubMed:9341151}.

Sigma Receptor CRISPR/Cas9 KO Plasmid (h) - sc-400615 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sigma Receptor HDR Plasmid (h) - sc-400615-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sigma Receptor Double Nickase Plasmid (h) - sc-400615-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sigma Receptor Double Nickase Plasmid (h2) - sc-400615-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sigma Receptor CRISPR Activation Plasmid (h) - sc-400615-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sigma Receptor CRISPR Activation Plasmid (h2) - sc-400615-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sigma Receptor Lentiviral Activation Particles (h) - sc-400615-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sigma Receptor Lentiviral Activation Particles (h2) - sc-400615-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sigma Receptor siRNA (h) - sc-42250 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sigma Receptor shRNA Plasmid (h) - sc-42250-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sigma Receptor shRNA (h) Lentiviral Particles - sc-42250-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sigma-1 R/OPRS1 RNAi - H00010280-R10 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Sigma-1 R/OPRS1 RNAi - H00010280-R06 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Sigma-1 R/OPRS1 RNAi - H00010280-R09 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Sigma-1 R/OPRS1 RNAi - H00010280-R08 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Sigma-1 R/OPRS1 RNAi - H00010280-R07 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN19339 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19339 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06804 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06804

SIGMAR1 siRNA (Human) - CRH6961 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SIGMAR1 - MBS8229687 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Sigma Receptor CRISPR/Cas9 KO Plasmid (h2) - sc-400615-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sigma Receptor HDR Plasmid (h2) - sc-400615-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human SIGMAR1 (NM_005866.2) - SHH407512 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human OPRS1(NM_147157.1) - SHR071538 from Creative biogene

Category siRNA
Species Reactivities Human
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