SIGMAR1

Gene Symbol	SIGMAR1
Entrez Gene	10280
Alt Symbol	ALS16, OPRS1, SIG-1R, SR-BP, SR-BP1, SRBP, hSigmaR1, sigma1R
Species	Human
Gene Type	protein-coding
Description	sigma non-opioid intracellular receptor 1
Other Description	SR31747 binding protein 1\|aging-associated gene 8 protein\|sigma 1-type opioid receptor
Swissprots	Q0Z9W6 Q8N7H3 O00725 Q9NYX0 Q153Z1 Q7Z653 Q2TSD1 Q99720 O00673 D3DRM7 Q53GN2
Accessions	AAC04507 EAW58431 EAW58434 EAW58435 EAW58436 EAW58437 Q99720 AF226604 AAF64280 AK098451 BAC05307 AK130502 AK222899 BAD96619 AK291092 BAF83781 AK299130 BAG61183 AY633611 AAV33304 BC004899 AAH04899 BC006307 BC007839 AAH07839 BC010104 BE018138 BI596428 CR457075 CAG33356 DQ644568 ABG29111 DQ647702 ABG36559 DQ656583 ABG46369 DQ892881 ABM83807 DQ896130 ABM87129 U75283 AAB50402 U79528 AAB51238 XM_011517674 XP_011515976 NM_001282205 NP_001269134 NM_001282206 NP_001269135 NM_001282207 NP_001269136 NM_001282208 NP_001269137 NM_001282209 NP_001269138 NM_005866 NP_005857 NM_147157 NP_671513 NR_104108 NM_147158 NM_147159 NM_147160
Function	Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. {ECO:0000269\|PubMed:16472803, ECO:0000269\|PubMed:9341151}.
Subcellular Location	Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Note=Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand- binding.
Tissue Specificity	Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. {ECO:0000269\|PubMed:11687279, ECO:0000269\|PubMed:8954936, ECO:0000269\|PubMed:9341151}.

Sigma Receptor (B-5) - sc-137075 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Sigma Receptor (B-5): sc-137075. Western blot analysis of Sigma Receptor expression in non-transfected 293T: sc-117752 (A), mouse Sigma Receptor transfected 293T: sc-125996 (B), SK-N-MC (C) and Hep G2 (D) whole cell lysates.

Sigma Receptor (F-5) - sc-166392 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Sigma Receptor (F-5): sc-166392. Western blot analysis of Sigma Receptor expression in JAR whole cell lysate.

Sigma Receptor (FL-223) - sc-20935 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Sigma Receptor (L-20) - sc-16203 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Sigma Receptor (L-20): sc-16203. Western blot analysis of Sigma Receptor expression in Hep G2 (A) and SK-N-MC (B) whole cell lysates.

Sigma Receptor (S-18) - sc-22948 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Sigma Receptor (S-18): sc-22948. Western blot analysis of Sigma Recep10302tor expression in JAR (A), Hep G2 (B), SK-N-MC (C) and T98G (D) whole cell lysates.

Anti-OPRS1 antibody - ab71446 from Abcam

Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-OPRS1 antibody (ab71446) at 1/50 dilutionLane 1 : Non transfected 293 cell lysateLane 2 : OPRS1 transfected 293 cell lysateLysates/proteins at 12.5 µg per lane.

Anti-OPRS1 antibody - ab89655 from Abcam

Prices	$373.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-OPRS1 antibody - ab71292 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-OPRS1 antibody (ab71292) at 1/50 dilutionLane 1 : Non-transfected 293 cell lysatesLane 2 : 293 cell lysates transiently transfected with the OPRS1 geneLysates/proteins at 12.5 µg per lane.

Anti-OPRS1 / SIGMAR1 Antibody (Internal) - LS-C145069 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-OPRS1 / SIGMAR1 Antibody - LS-C341630 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-OPRS1 / SIGMAR1 Antibody (aa47-81) - LS-C98622 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Western blot of OPRS1 (arrow) using rabbit polyclonal OPRS1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2) (Origene Technologies).

Anti-OPRS1 / SIGMAR1 Antibody - LS-C335575 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of various cell lines, using SIGMAR1 antibody.

Anti-OPRS1 / SIGMAR1 Antibody (aa118-147) - LS-C98623 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

OPRS1 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The OPRS1 antibody detected the OPRS1 protein (arrow).

Sigma-1 R/OPRS1 Antibody - NBP1-82479 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Sigma-1 R/OPRS1 Antibody [NBP1-82479] - Analysis in human cell line HeLa.

Sigma-1 R/OPRS1 Antibody - NBP2-19628 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Sigma-1 R/OPRS1 Antibody [NBP2-19628] - Sample (30 ug of whole cell lysate) A: 293T 12% SDS PAGE gel, diluted at 1:1000.

Sigma-1 R/OPRS1 Antibody - NBP1-30014 from Novus Biologicals

Prices	$329.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

OPRS1 Polyclonal Antibody - bs-5111R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti Sigma1R/OPRS1/Sigma Receptor Polyclonal Antibody, Unconjugated (bs-5111R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-SIGMAR1 antibody produced in rabbit - SAB2701222 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-SIGMAR1: <B>Cat. No. SAB2701222</B>: Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using SIGMAR1 antibody at 1:250 dilution.

Anti-SIGMAR1 antibody produced in rabbit - HPA018002 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-OPRS1: <B>Cat. No. HPA018002</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human small intestine shows distinct positivity in glandular cells.

ANTI-OPRS1 (CENTER) antibody produced in rabbit - SAB1305334 from Sigma-Aldrich

Prices	$326.00
Sizes	40 tst
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-OPRS1 (Center): <B>Cat. No. SAB1305334</B>: Western blot analysis of OPRS1 (arrow) using Rabbit polyclonal OPRS1 (Center) . 293 cell lysates (2 μg). <BR/><B>Lanes:</B><BR/>1. Nontransfected with the OPRS1 gene<BR/>2. Transiently transfected with the OPRS1 gene

ANTI-OPRS1(N-TERMINAL) antibody produced in rabbit - SAB1305361 from Sigma-Aldrich

Prices	$326.00
Sizes	40 tst
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-OPRS1 (N-term): <B>Cat. No. SAB1305361</B>: Western blot analysis of OPRS1 (arrow) using Rabbit polyclonal OPRS1 (N-term) . 293 cell lysates (2 μg) <BR/><B>Lanes:</B><BR/>1. Nontransfected with the OPRS1 gene<BR/>2. Transiently transfected with the OPRS1 gene

Anti-SIGMAR1 antibody produced in rabbit - HPA024071 from Sigma-Aldrich

Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-SIGMAR1: <B>Cat. No. HPA024071</B>: Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.

SIGMAR1 Antibody - N-terminal region (OAAB01426) - OAAB01426 from Aviva Systems Biology

Prices	$289.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

SIGMAR1 Antibody - middle region (OAAB01427) - OAAB01427 from Aviva Systems Biology

Prices	$289.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

OPRS1-Antibody-Center - AP2747c from Abgent, a WuXi AppTec company

Prices	$99.00, $295.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of OPRS1 (arrow) using rabbit polyclonal OPRS1 Antibody (Center) (Cat.#AP2747c).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2) (Origene Technologies).

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