| Gene Symbol |
Ifnlr1
|
| Entrez Gene |
242700
|
| Alt Symbol |
CRF2-12, Il28ra
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
interferon lambda receptor 1
|
| Other Description |
IFN-lambda R1|IL-28 receptor subunit alpha|IL-28R-alpha|IL-28RA|class II cytokine receptor 12|cytokine receptor class-II member 12|cytokine receptor family 2 member 12|interferon-lambda receptor 1|interleukin 28 receptor alpha|interleukin-28 receptor subunit alpha
|
| Swissprots |
Q6PEV1 Q8CGK5
|
| Accessions |
EDL29971 Q8CGK5 AK141338 BAE24654 AK148133 AK205737 AY184376 AAN86129 BC057856 AAH57856 NM_174851 NP_777276
|
| Function |
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. {ECO:0000269|PubMed:18250457, ECO:0000269|PubMed:21518880}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|