Ifnlr1

Gene Symbol Ifnlr1
Entrez Gene 242700
Alt Symbol CRF2-12, Il28ra
Species Mouse
Gene Type protein-coding
Description interferon lambda receptor 1
Other Description IFN-lambda R1|IL-28 receptor subunit alpha|IL-28R-alpha|IL-28RA|class II cytokine receptor 12|cytokine receptor class-II member 12|cytokine receptor family 2 member 12|interferon-lambda receptor 1|interleukin 28 receptor alpha|interleukin-28 receptor subunit alpha
Swissprots Q6PEV1 Q8CGK5
Accessions EDL29971 Q8CGK5 AK141338 BAE24654 AK148133 AK205737 AY184376 AAN86129 BC057856 AAH57856 NM_174851 NP_777276
Function The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. {ECO:0000269|PubMed:18250457, ECO:0000269|PubMed:21518880}.
Subcellular Location Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Recombinant Mouse IL-28 R alpha/IFN-lambda R1 Fc Chimera, CF - 5384-MR-050 from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse Ifnlr1, Fc Chimera - Ifnlr1-341M from Creative Biomart

Category Protein
Source NSO cells
Species Mouse

Recombinant Mouse Interleukin 28 Receptor Alpha, Fc-tagged - Il28ra-5658M from Creative Biomart

Category Protein
Source Murine myeloma cellline, NS0-derived.

Recombinant Mouse Interleukin-28 receptor subunit alpha(Il28ra) - CSB-YP806069MO CSB-EP806069MO CSB-BP806069MO CSB-MP806069MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse IL-28 R alpha/IFN-lambda R1 Fc Chimera, CF - 5384-MR from R&D Systems

Category Protein
Prices $329.00
Sizes 50 µg
Source Mouse myeloma cell line, NS0-derived Mouse IL-28 R alpha (Arg21 - Ala227) Accession # AAH57856 IEGRMDP Mouse IgG 2A (Glu98 - Lys330) N-terminus C-terminus
Species Mouse

Interleukin-28 receptor subunit alpha (Il28ra), Recombinant Protein - MBS1380818 from MyBioSource

Category Protein
Prices $955.00, $955.00, $1,180.00, $1,180.00, $1,430.00, $1,430.00, $1,895.00, $1,895.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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