| Gene Symbol |
KIAA1033
|
| Entrez Gene |
23325
|
| Alt Symbol |
MRT43, SWIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
KIAA1033
|
| Other Description |
WASH complex subunit 7|strumpellin and WASH-interacting protein
|
| Swissprots |
Q2M389 Q2NL83 Q8N5W7 Q9UPW7 Q9NVD6 Q8IW61
|
| Accessions |
EAW97758 EAW97759 EAW97760 EAW97761 Q2M389 AB028956 BAA82985 AF075010 AI753633 AK001657 BAA91816 AK001728 AK023146 AK026950 AK027218 AL137753 BC012556 BC031358 AAH31358 BC040936 AAH40936 BC104992 AAI04993 BC104994 AAI04995 BC110850 AAI10851 BC143373 AAI43374 XM_005268746 XP_005268803 XM_011538073 XP_011536375 XM_011538074 XP_011536376 XM_011538075 XP_011536377 XM_011538076 XP_011536378 XM_011538077 XP_011536379 XR_944511 NM_001293640 NP_001280569 NM_015275 NP_056090
|
| Function |
Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes sems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in the regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). {ECO:0000250|UniProtKB:Q3UMB9, ECO:0000303|PubMed:21498477, ECO:0000305|PubMed:19922875, ECO:0000305|PubMed:20498093}.
|
| Subcellular Location |
Early endosome {ECO:0000269|PubMed:23676666}.
|