CHMP1B

Gene Symbol	CHMP1B
Entrez Gene	57132
Alt Symbol	C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2, Vps46B, hVps46-2
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 1B
Other Description	charged multivesicular body protein 1b|chromatin modifying protein 1B|chromatin-modifying protein 1b|vacuolar protein sorting 46-2|vacuolar protein sorting-associated protein 46-2
Swissprots	Q9HD41 Q96E89 Q7LBR1
Accessions	AAL48200 EAX01575 Q7LBR1 AF281064 AAG01449 AK314068 BAG36769 BC012733 AAH12733 BC065933 AAH65933 BX494191 HQ448716 ADQ33194 NM_020412 NP_065145
Function	Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane
Subcellular Location	Cytoplasm, cytosol. Endosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body.
Tissue Specificity	Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain. {ECO:0000269|PubMed:11474171}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CHMP1B full length protein - ab126679 from Abcam Category Protein Source E. coli Species Human

C10orf2 / PEO1 Antibody Blocking Peptide - LS-E1947 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

C10orf2 / PEO1 Antibody Blocking Peptide - LS-E13070 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHMP1B Antibody Blocking Peptide - LS-E20959 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PEO1 Protein - H00056652-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human PEO1 Protein - H00056652-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CHMP1B Protein - H00057132-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CHMP1B Protein - H00057132-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CHMP1B-Antibody-N-term-Blocking-peptide - BP12720a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CHMP1B protein - orb168112 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Source E. coli

CHMP1B Blocking Peptide - 33R-4435 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CHMP1B protein (His tag) - 80R-2311 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

CHMP1B (1-199, His-tag) - AR50395PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

CHMP1B (1-199, His-tag) - AR50395PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

CHMP1B - H00057132-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CHMP1B - H00057132-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CHMP1B - H00057132-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CHMP1B - H00057132-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CHMP1B, 1-199aa, Human, His tag, E.coli - 01-P1571 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

CHMP1B fusion protein - Ag6222 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CHMP1B fusion protein - Ag6352 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CHMP1B, 1-199aa , Human, His tag, E.coli - GWB-P0467L from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 20 μg, 100 μg Source E.coli Species Human

Recombinant Human Charged Multivesicular Body Protein 1B, His-tagged - CHMP1B-6794H from Creative Biomart Category Protein

Recombinant Human CHMP1B, GST-tagged - CHMP1B-11183H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Charged multivesicular body protein 1b(CHMP1B) - CSB-YP748726HU CSB-EP748726HU CSB-BP748726HU CSB-MP748726HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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