CHMP1B
| Gene Symbol | CHMP1B |
|---|---|
| Entrez Gene | 57132 |
| Alt Symbol | C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2, Vps46B, hVps46-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | charged multivesicular body protein 1B |
| Other Description | charged multivesicular body protein 1b|chromatin modifying protein 1B|chromatin-modifying protein 1b|vacuolar protein sorting 46-2|vacuolar protein sorting-associated protein 46-2 |
| Swissprots | Q9HD41 Q96E89 Q7LBR1 |
| Accessions | AAL48200 EAX01575 Q7LBR1 AF281064 AAG01449 AK314068 BAG36769 BC012733 AAH12733 BC065933 AAH65933 BX494191 HQ448716 ADQ33194 NM_020412 NP_065145 |
| Function | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane |
| Subcellular Location | Cytoplasm, cytosol. Endosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body. |
| Tissue Specificity | Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain. {ECO:0000269|PubMed:11474171}. |
| Top Pathways | Endocytosis |
CHMP1B CRISPR/Cas9 KO Plasmid (h) - sc-406531 from Santa Cruz Biotechnology
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CHMP1B HDR Plasmid (h) - sc-406531-HDR from Santa Cruz Biotechnology
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CHMP1B Double Nickase Plasmid (h) - sc-406531-NIC from Santa Cruz Biotechnology
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CHMP1B Double Nickase Plasmid (h2) - sc-406531-NIC-2 from Santa Cruz Biotechnology
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CHMP1B CRISPR Activation Plasmid (h) - sc-406531-ACT from Santa Cruz Biotechnology
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CHMP1B CRISPR Activation Plasmid (h2) - sc-406531-ACT-2 from Santa Cruz Biotechnology
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CHMP1B Lentiviral Activation Particles (h) - sc-406531-LAC from Santa Cruz Biotechnology
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CHMP1B Lentiviral Activation Particles (h2) - sc-406531-LAC-2 from Santa Cruz Biotechnology
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CHMP1B siRNA (h) - sc-72893 from Santa Cruz Biotechnology
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CHMP1B shRNA Plasmid (h) - sc-72893-SH from Santa Cruz Biotechnology
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CHMP1B shRNA (h) Lentiviral Particles - sc-72893-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN6069 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6069 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05574 from Sigma-Aldrich
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CHMP1B siRNA (Human) - CRJ1346 from Cohesion Biosciences
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CHMP1B RNAi - H00057132-R01 from Novus Biologicals
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CHMP1B - MBS8207128 from MyBioSource
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CHMP1B CRISPR/Cas9 KO Plasmid (h2) - sc-406531-KO-2 from Santa Cruz Biotechnology
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CHMP1B HDR Plasmid (h2) - sc-406531-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CHMP1B (NM_020412.4) - SHH263177 from Creative biogene
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CHMP1B shRNA Plasmid (Human) - CHJ1346 from Cohesion Biosciences
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CHMP1B miRNA 3'UTR clone - MiUTR4H-TG02081 from Creative biogene
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