CHMP1B

Gene Symbol CHMP1B
Entrez Gene 57132
Alt Symbol C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2, Vps46B, hVps46-2
Species Human
Gene Type protein-coding
Description charged multivesicular body protein 1B
Other Description charged multivesicular body protein 1b|chromatin modifying protein 1B|chromatin-modifying protein 1b|vacuolar protein sorting 46-2|vacuolar protein sorting-associated protein 46-2
Swissprots Q9HD41 Q96E89 Q7LBR1
Accessions AAL48200 EAX01575 Q7LBR1 AF281064 AAG01449 AK314068 BAG36769 BC012733 AAH12733 BC065933 AAH65933 BX494191 HQ448716 ADQ33194 NM_020412 NP_065145
Function Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane
Subcellular Location Cytoplasm, cytosol. Endosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body.
Tissue Specificity Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain. {ECO:0000269|PubMed:11474171}.
Top Pathways Endocytosis

CHMP1B (D-10) - sc-514013 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CHMP1B (D-10): sc-514013. Western blot analysis of CHMP1B expression in non-transfected 293T: sc-117752 (A), mouse CHMP1B transfected 293T: sc-119239 (B) and HeLa (C) whole cell lysates.

CHMP1B (C-20) - sc-69547 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CHMP1B (C-20): sc-69547. Western blot analysis of CHMP1B expression in non-transfected 293T: sc-117752 (A), mouse CHMP1B transfected 293T: sc-119239 (B) and HeLa (C) whole cell lysates and mouse thyroid tissue extract (D).

Anti-CHMP1B antibody - ab105706 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CHMP1B antibody (ab105706) at 1 µg/ml + Human fetal heart lysate at 10 µg

Anti-CHMP1B Antibody (aa35-84) - LS-C112055 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CHMP1B antibody LS-C112055 Western blot of Fetal Heart lysate.

CHMP1B Antibody - NBP1-55512 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

CHMP1B Antibody - NBP2-38007 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: CHMP1B Antibody [NBP2-38007] - Staining of human pancreas shows moderate granular cytoplasmic positivity in exocrine glandular cells.

CHMP1B Antibody - NBP2-37986 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: CHMP1B Antibody [NBP2-37986] - Staining of human cell line U-2 OS shows localization to nucleus & midbody.

CHMP1B Polyclonal Antibody - bs-7789R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CHMP1B (116-129) antibody produced in rabbit - SAB1102425 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human CHMP1B was separated on SDS-PAGE, blotted with Anti-CHMP1B (116-129) (<B>Cat. No. SAB1102425</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500 <BR/>2. Antibody dilution 1:500 + CHMP1B immunizing peptide (human, 116-129)

CHMP1B antibody - N-terminal region (ARP57408_P050) - ARP57408_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

chmp1b antibody - zf124894 from GeneTex

Host Rabbit
Clonality Polyclonal

CHMP1B antibody [N1C3] - GTX118508 from GeneTex

Host Rabbit
Clonality Polyclonal

PEO1 antibody - 70R-4802 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

CHMP1B antibody - 70R-16396 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

CHMP1B antibody - 70R-4086 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

C10orf2 Antibody - abx027021 from Abbexa

Prices $490.00, $490.00, $490.00, $490.00
Sizes 10 μl, 50 μl, 100 μl, 200 μl
Host Rabbit
Clonality Polyclonal

C10orf2 Antibody - abx004053 from Abbexa

Prices $490.00, $490.00, $490.00, $490.00
Sizes 10 μl, 50 μl, 100 μl, 200 μl
Host Rabbit
Clonality Polyclonal

Chromatin Modifying Protein 1B Antibody - abx111628 from Abbexa

Prices $490.00, $490.00, $490.00, $490.00
Sizes 10 μl, 50 μl, 100 μl, 200 μl
Host Rabbit
Clonality Polyclonal

CHMP1B antibody - 14639-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded H-kidney(glomerulus) using 14639-1-AP(CHMP1B Antibody) at Dilution 1:50 (under 10x lens)

CHMP1B antibody - H00057132-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

CHMP1B antibody - 14639-1-AP from Proteintech Group

Prices $279.00
Sizes con: 20 μg/150μl
Host Rabbit
Clonality Polyclonal
HeLa cells were subjected to SDS PAGE followed by western blot with 14639-1-AP(CHMP1B antibody) at dilution of 1:300

C10orf2, Polyclonal Antibody - MBS2529008 from MyBioSource

Prices $195.00, $270.00, $435.00
Sizes 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

CHMP1B Antibody - GWB-MU816F from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

CHMP1B, Polyclonal Antibody - MBS2518494 from MyBioSource

Prices $195.00, $270.00, $435.00
Sizes 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal
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