Gene Symbol | NANS |
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Entrez Gene | 54187 |
Alt Symbol | HEL-S-100, SAS |
Species | Human |
Gene Type | protein-coding |
Description | N-acetylneuraminic acid synthase |
Other Description | N-acetylneuraminate synthase|N-acetylneuraminate-9-phosphate synthase|N-acetylneuraminic acid phosphate synthase|epididymis secretory protein Li 100|sialic acid phosphate synthase|sialic acid synthase |
Swissprots | Q9NVD4 Q8WUV9 Q9NR45 Q9BWS6 B2RE98 |
Accessions | EAW58866 EAW58867 EAW58868 EAW58869 Q9NR45 AF161387 AAF28947 AF257466 AAF75261 AK001659 BAA91818 AK091184 AK316608 BAG38195 AL526281 BC000008 AAH00008 BC019315 AAH19315 BQ446501 DQ892167 ABM83093 DQ895361 ABM86287 FJ224349 ACI46041 XM_011518787 XP_011517089 XM_011518788 XP_011517090 NM_018946 NP_061819 |
Function | Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Amino sugar and nucleotide sugar metabolism |
NANS CRISPR/Cas9 KO Plasmid (h) - sc-412267 from Santa Cruz Biotechnology
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NANS HDR Plasmid (h) - sc-412267-HDR from Santa Cruz Biotechnology
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NANS Double Nickase Plasmid (h) - sc-412267-NIC from Santa Cruz Biotechnology
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NANS Double Nickase Plasmid (h2) - sc-412267-NIC-2 from Santa Cruz Biotechnology
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NANS CRISPR Activation Plasmid (h) - sc-412267-ACT from Santa Cruz Biotechnology
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NANS CRISPR Activation Plasmid (h2) - sc-412267-ACT-2 from Santa Cruz Biotechnology
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NANS Lentiviral Activation Particles (h) - sc-412267-LAC from Santa Cruz Biotechnology
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NANS Lentiviral Activation Particles (h2) - sc-412267-LAC-2 from Santa Cruz Biotechnology
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NANS siRNA (h) - sc-92845 from Santa Cruz Biotechnology
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NANS shRNA Plasmid (h) - sc-92845-SH from Santa Cruz Biotechnology
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NANS shRNA (h) Lentiviral Particles - sc-92845-V from Santa Cruz Biotechnology
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NANS RNAi - H00054187-R01 from Novus Biologicals
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MISSION® esiRNA - EHU097381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14944 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14944 from Sigma-Aldrich
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NANS siRNA (Human) - CRJ0028 from Cohesion Biosciences
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shRNA set against Human NANS (NM_018946.3) - SHH349216 from Creative biogene
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NANS shRNA Plasmid (Human) - CHJ0028 from Cohesion Biosciences
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NANS miRNA 3'UTR clone - MiUTR4H-TG05835 from Creative biogene
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