NCLN

Gene Symbol	NCLN
Entrez Gene	56926
Alt Symbol	NET59
Species	Human
Gene Type	protein-coding
Description	nicalin
Other Description	nicalin homolog (zebrefish)\|nicastrin-like protein
Swissprots	Q96H48 Q6ZMB7 Q9BTX4 Q8TAT7 Q6FI60 D6W613 O75252 Q96IS7 Q9BQH9 Q969V3 Q9NPP2
Accessions	AAC27667 CAC16637 CAW38766 CAW54087 CBC04638 CBC26779 EAW69330 EAW69331 EAW69332 EAW69333 EAW69334 EAW69335 Q969V3 AK022309 AK125002 AK172848 BAD18812 AK314044 BAG36753 AL136567 CAB66502 AL365369 CAB96945 AM393010 CAL37888 BC003076 AAH03076 BC007275 AAH07275 BC008920 AAH08920 BC010064 AAH10064 BC013283 AAH13283 BC019091 AAH19091 BC025926 AAH25926 CR533566 CAG38597 XM_005259596 XP_005259653 NM_020170 NP_064555
Function	May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. {ECO:0000250}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:15257293, ECO:0000269\|PubMed:20538592}; Single-pass membrane protein {ECO:0000269\|PubMed:15257293, ECO:0000269\|PubMed:20538592}.
Tissue Specificity	Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. {ECO:0000269\|PubMed:15257293}.

Nicalin (E-18) - sc-65148 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Nicalin (L-17) - sc-65150 from Santa Cruz Biotechnology

Prices	$61.00
Sizes	100 µg/0.5 ml
Host	Goat
Clonality	Polyclonal

Anti-NCLN antibody - ab140184 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunofluorescence of NCLN in Human heart tissue with ab140184 at 20 ug/mL.

Anti-NCLN antibody - ab127175 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NCLN antibody (ab127175) at 1/1000 dilution + HeLa cell lysate at 30 µg

Anti-NCLN antibody [EPR8528] - ab131159 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8528

All lanes : Anti-NCLN antibody [EPR8528] (ab131159) at 1/1000 dilutionLane 1 : A431 cell lysateLane 2 : BxPC-3 cell lysateLane 3 : 293T cell lysateLane 4 : C6 cell lysateLane 5 : Raw 264.7 cell lysateLane 6 : NIH/3T3 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit IgG at 1/2000 dilution

Anti-NCLN antibody [EPR8529] - ab170100 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8529

All lanes : Anti-NCLN antibody [EPR8529] (ab170100) at 1/1000 dilutionLane 1 : A431 cell lysateLane 2 : HeLa cell lysateLane 3 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-NCLN Antibody (aa470-519) - LS-C152150 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NCLN Antibody (Internal, clone EPR8528) - LS-C154536 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8528

Western blot analysis on (A) A431, (B) BxPC-3, (C) 293T, (D) C6, (E) Raw 264.7, and (F) NIH/3T3 cell lysates using anti-NCLN antibody.

Anti-NCLN Antibody (Internal) - LS-C155541 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Sample (30 ug of whole cell lysate) A: HeLa 7.5% SDS PAGE NCLN antibody diluted at 1:1000

Anti-NCLN Antibody (aa474-523) - LS-C199301 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from HepG2/HUVEC cells, using NCLN Antibody. The lane on the right was incubated with synthetic peptide.

Anti-NCLN Antibody (C-Terminus) - LS-C153682 from LifeSpan Bioscience

Prices	$345.00, $1,035.00
Sizes	100 µg, 500 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of NCLN in human heart tissue with NCLN antibody at 2.5 ug/ml.

Nicalin Antibody - NBP1-81002 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Nicalin Antibody [NBP1-81002] - Analysis of mouse brain lysate. Image from verified customer review.

Nicalin Antibody - AF7686 from Novus Biologicals

Prices	$99.00, $359.00
Sizes	25 µg, 100 µg
Host	Sheep
Clonality	Polyclonal

Western blot shows lysates of HT‑29 human colon adenocarcinoma cell line, CEM human T-lymphoblastoid cell line, Huh‑7 human hepatoma cell line, Neuro‑2A mouse neuroblastoma cell line, and NR8383 rat alveolar macrophage cell line. PVDF membrane was probed with 0.5 µg/mL of Sheep Anti-Human/Mouse/Rat Nicalin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7686) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Nicalin at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Nicalin Antibody - NBP2-19494 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Nicalin Antibody - NBP2-19493 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Nicalin Antibody [NBP2-19493] - Sample (30 ug of whole cell lysate) A: HeLa 7. 5% SDS PAGE gel, diluted at 1:1000.

Nicalin Antibody - H00056926-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: Nicalin Antibody [H00056926-A01] - NCLN polyclonal antibody (A01), Lot # 060703JCS1. Western Blot analysis of NCLN expression in Daoy.

Nicalin/NCLN Polyclonal Antibody - bs-11594R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-Nicalin/NCLN Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11594R-A350 from Bioss

Prices	$325.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-Nicalin/NCLN Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11594R-A488 from Bioss

Prices	$325.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-Nicalin/NCLN Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11594R-A555 from Bioss

Prices	$325.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-Nicalin/NCLN Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11594R-A647 from Bioss

Prices	$325.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-Nicalin/NCLN Polyclonal Antibody, Cy3 Conjugated - bs-11594R-Cy3 from Bioss

Prices	$345.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-Nicalin/NCLN Polyclonal Antibody, Cy5 Conjugated - bs-11594R-Cy5 from Bioss

Prices	$345.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-Nicalin/NCLN Polyclonal Antibody, Cy5.5 Conjugated - bs-11594R-Cy5.5 from Bioss

Prices	$345.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-Nicalin/NCLN Polyclonal Antibody, Cy7 Conjugated - bs-11594R-Cy7 from Bioss

Prices	$345.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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