Gene Symbol | EPS15L1 |
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Entrez Gene | 58513 |
Alt Symbol | EPS15R |
Species | Human |
Gene Type | protein-coding |
Description | epidermal growth factor receptor pathway substrate 15-like 1 |
Other Description | epidermal growth factor receptor substrate 15-like 1|epidermal growth factor receptor substrate EPS15R|eps15-related protein |
Swissprots | A5PL29 Q9UBC2 A2RRF3 B4DKA3 |
Accessions | EAW84542 EAW84543 EAW84544 EAW84545 Q9UBC2 AB015346 BAA88118 AF110265 AAF21930 AK023744 AK024166 BAG51266 AK025770 AK291359 BAF84048 AK296473 BAG59115 AK297428 BAG59856 AK299001 BAG61087 AL110270 CAH10724 AU121887 BC037558 BC051873 BC067114 BC131590 AAI31591 BC142662 AAI42663 BC142716 AAI42717 BU075732 CA311813 CA446537 DC416977 NM_001258374 NP_001245303 NM_001258375 NP_001245304 NM_001258376 NP_001245305 NM_021235 NP_067058 NR_047665 NR_047666 |
Function | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, coated pit {ECO:0000250}. Note=Localized to plasma membrane coated pits. {ECO:0000250}. |
Eps15R CRISPR/Cas9 KO Plasmid (h) - sc-408531 from Santa Cruz Biotechnology
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Eps15R HDR Plasmid (h) - sc-408531-HDR from Santa Cruz Biotechnology
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Eps15R Double Nickase Plasmid (h) - sc-408531-NIC from Santa Cruz Biotechnology
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Eps15R Double Nickase Plasmid (h2) - sc-408531-NIC-2 from Santa Cruz Biotechnology
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Eps15R CRISPR Activation Plasmid (h) - sc-408531-ACT from Santa Cruz Biotechnology
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Eps15R CRISPR Activation Plasmid (h2) - sc-408531-ACT-2 from Santa Cruz Biotechnology
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Eps15R Lentiviral Activation Particles (h) - sc-408531-LAC from Santa Cruz Biotechnology
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Eps15R Lentiviral Activation Particles (h2) - sc-408531-LAC-2 from Santa Cruz Biotechnology
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Eps15R siRNA (h) - sc-40507 from Santa Cruz Biotechnology
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Eps15R shRNA Plasmid (h) - sc-40507-SH from Santa Cruz Biotechnology
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Eps15R shRNA (h) Lentiviral Particles - sc-40507-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU036601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7934 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7934 from Sigma-Aldrich
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EPS15L1 siRNA (Human) - CRJ1740 from Cohesion Biosciences
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EPS15R RNAi - H00058513-R01 from Novus Biologicals
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EPS15L1 - MBS8220184 from MyBioSource
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shRNA set against Human EPS15L1 (NM_021235.2) - SHH286657 from Creative biogene
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EPS15L1 shRNA Plasmid (Human) - CHJ1740 from Cohesion Biosciences
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EPS15L1 miRNA 3'UTR clone - MiUTR3H-13537 from Creative biogene
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