OPTN

Gene Symbol	OPTN
Entrez Gene	10133
Alt Symbol	ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Species	Human
Gene Type	protein-coding
Description	optineurin
Other Description	E3-14.7K-interacting protein|FIP-2|HIP-7|Huntingtin interacting protein L|huntingtin yeast partner L|huntingtin-interacting protein 7|huntingtin-interacting protein L|nemo-related protein|optic neuropathy-inducing protein|transcription factor IIIA-interacting protein|transcrption factor IIIA-interacting protein|tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
Swissprots	Q5T674 B3KP00 Q8N562 Q5T673 Q7LDL9 Q96CV9 Q9Y218 D3DRS8 Q9UEV4 Q5T675 Q9UET9 D3DRS4 Q5T672
Accessions	AAG00497 EAW86301 EAW86302 EAW86303 EAW86304 EAW86305 EAW86306 EAW86307 EAW86308 EAW86309 Q96CV9 AF049614 AAC26850 AF061034 AAC16046 AF070533 AF420371 AAL76327 AF420372 AAL76328 AF420373 AAL76329 AK055403 BAG51512 AK122746 AK303715 BAG64696 AK316171 BAH14542 BC013876 AAH13876 BC032762 AAH32762 BI552635 DQ893651 ABM84577 DQ895820 ABM86746 XM_005252336 XP_005252393 XM_005252337 XP_005252394 XM_005252338 XP_005252395 NM_001008211 NP_001008212 NM_001008212 NP_001008213 NM_001008213 NP_001008214 NM_021980 NP_068815
Function	Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MA
Subcellular Location	Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy.
Tissue Specificity	Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:9488477}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

OPTN-Over-expression-Lysate - LY14183a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

OPTN 293T Cell Transient Overexpression Lysate(Denatured) - H00010133-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

OPTN overexpression lysate - LY411824 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

OPTN overexpression lysate - LY423390 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

OPTN overexpression lysate - LY423391 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

OPTN overexpression lysate - LY423392 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

OPTN overexpression lysate - LY425228 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

OPTN overexpression lysate - LY425229 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

OPTN overexpression lysate - LY429664 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

OPTN 293 Cell Lysate - 409926 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Optineurin Overexpression Lysate (Native) - NBL1-13949 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Optineurin Overexpression Lysate (Native) - NBP2-06486 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Optineurin (h): 293T Lysate - sc-114995 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Optineurin (h2): 293T Lysate - sc-170133 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

OPTN Over-expression Lysate Product - GWB-C991FC from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human Optineurin / OPTN Insect Cell Lysate (WB positive control) - 14478-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human OPTN Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175290 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Optineurin Overexpression Lysate (Native) - NBP2-11265 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Optineurin Overexpression Lysate (Native) - NBP2-10996 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Optineurin Overexpression Lysate (Native) - NBP2-10995 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Optineurin Overexpression Lysate (Native) - NBP2-11186 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Optineurin Overexpression Lysate (Native) - NBP2-11185 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Optineurin Overexpression Lysate (Denatured) - H00010133-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Optineurin Overexpression Lysate (Denatured) - H00010133-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human OPTN Knockdown Stable Cell Line - CSC-DC010866 from Creative biogene Category Cell Line Species Human

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