OPTN

Gene Symbol OPTN
Entrez Gene 10133
Alt Symbol ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Species Human
Gene Type protein-coding
Description optineurin
Other Description E3-14.7K-interacting protein|FIP-2|HIP-7|Huntingtin interacting protein L|huntingtin yeast partner L|huntingtin-interacting protein 7|huntingtin-interacting protein L|nemo-related protein|optic neuropathy-inducing protein|transcription factor IIIA-interacting protein|transcrption factor IIIA-interacting protein|tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
Swissprots Q5T674 B3KP00 Q8N562 Q5T673 Q7LDL9 Q96CV9 Q9Y218 D3DRS8 Q9UEV4 Q5T675 Q9UET9 D3DRS4 Q5T672
Accessions AAG00497 EAW86301 EAW86302 EAW86303 EAW86304 EAW86305 EAW86306 EAW86307 EAW86308 EAW86309 Q96CV9 AF049614 AAC26850 AF061034 AAC16046 AF070533 AF420371 AAL76327 AF420372 AAL76328 AF420373 AAL76329 AK055403 BAG51512 AK122746 AK303715 BAG64696 AK316171 BAH14542 BC013876 AAH13876 BC032762 AAH32762 BI552635 DQ893651 ABM84577 DQ895820 ABM86746 XM_005252336 XP_005252393 XM_005252337 XP_005252394 XM_005252338 XP_005252395 NM_001008211 NP_001008212 NM_001008212 NP_001008213 NM_001008213 NP_001008214 NM_021980 NP_068815
Function Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MA
Subcellular Location Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy.
Tissue Specificity Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:9488477}.

Optineurin (C-1) - sc-271549 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Optineurin (C-1): sc-271549. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic staining of glandular cells.

Optineurin (C-2) - sc-166576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Optineurin (C-2): sc-166576. Western blot analysis of Optineurin expression in non-transfected 293T: sc-117752 (A), human Optineurin transfected 293T: sc-170133 (B), Jurkat (C), Sol8 (D) and L6 (E) whole cell lysates and HeLa nuclear extract (F).

Optineurin (8) - sc-136364 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Optineurin (8): sc-136364. Western blot analysis of Optineurin expression in HeLa whole cell lysate.

Optineurin (K-14) - sc-48901 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Optineurin (K-14): sc-48901. Western blot analysis of Optineurin expression in non-transfected: sc-117752 (A) and human Optineurin transfected: sc-170133 (B) 293T whole cell lysates.

Optineurin (N-18) - sc-48903 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Optineurin (N-18): sc-48903. Western blot analysis of Optineurin expression in non-transfected: sc-117752 (A) and human Optineurin transfected: sc-114995 (B) 293T whole cell lysates.

Optineurin (H-220) - sc-99214 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Optineurin (H-220): sc-99214. Western blot analysis of Optineurin expression in Jurkat whole cell lysate.

Anti-Optineurin antibody - ab151240 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Optineurin antibody (ab151240) at 1/2000 dilutionLane 1 : A431 whole cell lysateLane 2 : H1299 whole cell lysateLane 3 : Hep G2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Optineurin antibody - ab101588 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Optineurin antibody - ab89820 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Optineurin antibody (ab89820) at 1 µg/ml + Human placenta tissue lysate at 50 µg

Anti-Optineurin antibody - ab79110 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal tissue, staining Optineurin with ab79110 at 5 µg/ml.

Anti-Optineurin antibody - ab23666 from Abcam

Prices $382.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
ab23666 staining Optineurin in HeLa cells and Retinal Ganglion Cell line 5 cells (RGC-5) by Immunocytochemistry/ Immunofluorescence.(A) HeLa cells were pulsed with Alexa-546® conjugated transferrin for 30 minutes, chased with unlabeled holo-transferrin for 20 minutes and stained for endogenous Optineurin.(B) RGC-5 cells were stained for endogenous Optineurin.

Anti-OPTN / Optineurin Antibody (aa70-96, AP) - LS-C223543 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPTN / Optineurin Antibody (aa72-121) - LS-C79998 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-OPTN / Optineurin Antibody (aa70-96, APC) - LS-C223544 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPTN / Optineurin Antibody (C-Terminus) - LS-C80594 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MCF7 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-OPTN / Optineurin Antibody (aa70-96, Biotin) - LS-C223545 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPTN / Optineurin Antibody (N-Terminus) - LS-C110398 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
OPTN / Optineurin antibody LS-C110398 Western blot of Transfected 293T cell lysate.

Anti-OPTN / Optineurin Antibody - LS-C152807 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB: Anti-optineurin on mouse retina lysate.

Anti-OPTN / Optineurin Antibody (aa70-96, PE) - LS-C226930 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPTN / Optineurin Antibody (aa70-96, Azide-free, HRP) - LS-C226929 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPTN / Optineurin Antibody (aa70-96, FITC) - LS-C226931 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPTN / Optineurin Antibody (aa1-50) - LS-C288604 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPTN / Optineurin Antibody (aa175-225) - LS-C288606 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPTN / Optineurin Antibody (aa70-96) - LS-C323533 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPTN / Optineurin Antibody (aa504-554) - LS-C288607 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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