| Gene Symbol | OPTN |
|---|---|
| Entrez Gene | 10133 |
| Alt Symbol | ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP |
| Species | Human |
| Gene Type | protein-coding |
| Description | optineurin |
| Other Description | E3-14.7K-interacting protein|FIP-2|HIP-7|Huntingtin interacting protein L|huntingtin yeast partner L|huntingtin-interacting protein 7|huntingtin-interacting protein L|nemo-related protein|optic neuropathy-inducing protein|transcription factor IIIA-interacting protein|transcrption factor IIIA-interacting protein|tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains |
| Swissprots | Q5T674 B3KP00 Q8N562 Q5T673 Q7LDL9 Q96CV9 Q9Y218 D3DRS8 Q9UEV4 Q5T675 Q9UET9 D3DRS4 Q5T672 |
| Accessions | AAG00497 EAW86301 EAW86302 EAW86303 EAW86304 EAW86305 EAW86306 EAW86307 EAW86308 EAW86309 Q96CV9 AF049614 AAC26850 AF061034 AAC16046 AF070533 AF420371 AAL76327 AF420372 AAL76328 AF420373 AAL76329 AK055403 BAG51512 AK122746 AK303715 BAG64696 AK316171 BAH14542 BC013876 AAH13876 BC032762 AAH32762 BI552635 DQ893651 ABM84577 DQ895820 ABM86746 XM_005252336 XP_005252393 XM_005252337 XP_005252394 XM_005252338 XP_005252395 NM_001008211 NP_001008212 NM_001008212 NP_001008213 NM_001008213 NP_001008214 NM_021980 NP_068815 |
| Function | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MA |
| Subcellular Location | Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy. |
| Tissue Specificity | Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:9488477}. |
Optineurin CRISPR/Cas9 KO Plasmid (h) - sc-401851 from Santa Cruz Biotechnology
|
||||||||
Optineurin HDR Plasmid (h) - sc-401851-HDR from Santa Cruz Biotechnology
|
||||||||
Optineurin Double Nickase Plasmid (h) - sc-401851-NIC from Santa Cruz Biotechnology
|
||||||||
Optineurin Double Nickase Plasmid (h2) - sc-401851-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Optineurin CRISPR Activation Plasmid (h) - sc-401851-ACT from Santa Cruz Biotechnology
|
||||||||
Optineurin CRISPR Activation Plasmid (h2) - sc-401851-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Optineurin Lentiviral Activation Particles (h) - sc-401851-LAC from Santa Cruz Biotechnology
|
||||||||
Optineurin Lentiviral Activation Particles (h2) - sc-401851-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Optineurin siRNA (h) - sc-39054 from Santa Cruz Biotechnology
|
||||||||
Optineurin shRNA Plasmid (h) - sc-39054-SH from Santa Cruz Biotechnology
|
||||||||
Optineurin shRNA (h) Lentiviral Particles - sc-39054-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU077201 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN15749 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15749 from Sigma-Aldrich
|
||||||||
OPTN siRNA (Human) - CRH6834 from Cohesion Biosciences
|
||||||||
shRNA set against Human OPTN (NM_021980.4) - SHH366768 from Creative biogene
|
||||||||
shRNA set against Human OPTN(NM_001008211.1) - SHR071850 from Creative biogene
|
||||||||
Human OPTN siRNA - orb267336 from Biorbyt
|
||||||||
OPTN shRNA Plasmid (Human) - CHH6834 from Cohesion Biosciences
|
||||||||
OPTN miRNA 3'UTR clone - MiUTR1H-07076 from Creative biogene
|
||||||||
OPTN miRNA 3'UTR clone - MiUTR3H-04981 from Creative biogene
|
||||||||
OPTN miRNA 3'UTR clone - MiUTR3H-04982 from Creative biogene
|
||||||||
OPTN miRNA 3'UTR clone - MiUTR3H-04983 from Creative biogene
|