MEF2A

Gene Symbol	MEF2A
Entrez Gene	4205
Alt Symbol	ADCAD1, RSRFC4, RSRFC9, mef2
Species	Human
Gene Type	protein-coding
Description	myocyte enhancer factor 2A
Other Description	MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)|myocyte-specific enhancer factor 2A|serum response factor-like protein 1
Swissprots	Q7Z6C9 Q02078 B4DFQ7 Q14223 Q96D14 O43814 Q59GX4 F6XG23 Q14224
Accessions	AAB17195 AAB17196 EAX02249 EAX02250 EAX02251 EAX02252 Q02078 AB208985 BAD92222 AK291835 BAF84524 AK294207 BAG57518 AL831995 AM392739 CAL37617 AM393856 CAL38731 BC013437 AAH13437 BC053871 AAH53871 DA778137 EU446488 ABZ92017 N93079 X63381 CAA44979 X68503 CAA48516 X68504 X68505 CAA48517 Y16312 CAA76175 XM_005254914 XP_005254971 XM_005254915 XP_005254972 XM_005254916 XP_005254973 XM_011521571 XP_011519873 XM_011521572 XP_011519874 XM_011521573 XP_011519875 XM_011521574 XP_011519876 XM_011521575 XP_011519877 XM_011521576 XP_011519878 XM_011521577 XP_011519879 XM_011521578 XP_011519880 XM_011521579 XP_011519881 XM_011521580 XP_011519882 XM_011521581 XP_011519883 XM_011521582 XP_011519884 XM_011521583 XP_011519885 XM_011521584 XP_011519886 XM_011521585 XP_011519887 XM_011521586 XP_011519888 XM_011521587 XP_011519889 XM_011521588 XP_011519890 XM_011521589 XP_011519891 XM_011521590 XP_011519892 XR_931837 NM_001130926 NP_001124398 NM_001130927 NP_001124399 NM_001130928 NP_001124400 NM_001171894 NP_001165365 NM_005587 NP_005578
Function	Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:16563226}.
Tissue Specificity	Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined. {ECO:0000269|PubMed:1516833, ECO:0000269|PubMed:1748287}.
Top Pathways	cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MEF2A full length protein - ab152519 from Abcam Category Protein Source Wheat germ Species Human

MEF2A peptide - ab151761 from Abcam Category Peptide

MEF2A / MEF2 Antibody Blocking Peptide - LS-E12118 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MEF2A / MEF2 Antibody Blocking Peptide - LS-E13905 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MEF2A / MEF2 Antibody Blocking Peptide - LS-E13906 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MEF2A / MEF2 Antibody Blocking Peptide - LS-E13336 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MEF2A / MEF2 Antibody Blocking Peptide - LS-E10029 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MEF2A Protein - H00004205-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MEF2A-Antibody-Center-Blocking-Peptide - BP9258c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MEF2A Protein Lysate (APL10812) - APL10812 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

MEF2A Protein Lysate (APL10813) - APL10813 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

MEF2A (phospho-Thr319) Blocking Peptide - abx062160 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken

MEF2A - H00004205-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MEF2A - H00004205-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MEF2A - H00004205-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MEF2A - H00004205-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MEF2A - H00004205-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MEF2A - H00004205-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MEF2A (1-499, Full Length) - PRO-50064-0010 from Acris Antibodies Category Protein Prices $205.00 Sizes 10 µg Source E. coli Species Human

MEF2A (1-499, Full Length) - PRO-50064-0025 from Acris Antibodies Category Protein Prices $235.00 Sizes 25 µg Source E. coli Species Human

MEF2A (1-499, Full Length) - PRO-50064-0050 from Acris Antibodies Category Protein Prices $320.00 Sizes 50 µg Source E. coli Species Human

MEF2A (1-499, Full Length) - PRO-50065-0010 from Acris Antibodies Category Protein Prices $205.00 Sizes 10 µg Source Sf9-Baculovirus Species Human

MEF2A (1-499, Full Length) - PRO-50065-0025 from Acris Antibodies Category Protein Prices $270.00 Sizes 25 µg Source Sf9-Baculovirus Species Human

MEF2A (1-499, Full Length) - PRO-50065-0050 from Acris Antibodies Category Protein Prices $440.00 Sizes 50 µg Source Sf9-Baculovirus Species Human

MEF2A fusion protein - ag3049 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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