MEF2A

Gene Symbol MEF2A
Entrez Gene 4205
Alt Symbol ADCAD1, RSRFC4, RSRFC9, mef2
Species Human
Gene Type protein-coding
Description myocyte enhancer factor 2A
Other Description MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)|myocyte-specific enhancer factor 2A|serum response factor-like protein 1
Swissprots Q7Z6C9 Q02078 B4DFQ7 Q14223 Q96D14 O43814 Q59GX4 F6XG23 Q14224
Accessions AAB17195 AAB17196 EAX02249 EAX02250 EAX02251 EAX02252 Q02078 AB208985 BAD92222 AK291835 BAF84524 AK294207 BAG57518 AL831995 AM392739 CAL37617 AM393856 CAL38731 BC013437 AAH13437 BC053871 AAH53871 DA778137 EU446488 ABZ92017 N93079 X63381 CAA44979 X68503 CAA48516 X68504 X68505 CAA48517 Y16312 CAA76175 XM_005254914 XP_005254971 XM_005254915 XP_005254972 XM_005254916 XP_005254973 XM_011521571 XP_011519873 XM_011521572 XP_011519874 XM_011521573 XP_011519875 XM_011521574 XP_011519876 XM_011521575 XP_011519877 XM_011521576 XP_011519878 XM_011521577 XP_011519879 XM_011521578 XP_011519880 XM_011521579 XP_011519881 XM_011521580 XP_011519882 XM_011521581 XP_011519883 XM_011521582 XP_011519884 XM_011521583 XP_011519885 XM_011521584 XP_011519886 XM_011521585 XP_011519887 XM_011521586 XP_011519888 XM_011521587 XP_011519889 XM_011521588 XP_011519890 XM_011521589 XP_011519891 XM_011521590 XP_011519892 XR_931837 NM_001130926 NP_001124398 NM_001130927 NP_001124399 NM_001130928 NP_001124400 NM_001171894 NP_001165365 NM_005587 NP_005578
Function Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:16563226}.
Tissue Specificity Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined. {ECO:0000269|PubMed:1516833, ECO:0000269|PubMed:1748287}.
Top Pathways cGMP-PKG signaling pathway

Phospho-MEF2A (Ser408) Antibody - 9737 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS-7 cells transfected with wild-type GAL4-MEF2A or mutant GAL4-MEF2A (S408A), using Phospho-MEF2A (Ser408) Antibody (top) and MEF2A Antibody #9736 (bottom).

MEF2A Antibody - 9736 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C2C12 and RD cells, using MEF2A Antibody.

MEF-2 (B-4) - sc-17785 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MEF-2 (B-4): sc-17785. Western blot analysis of MEF-2 expression in non-transfected: sc-110760 (A) and human MEF-2 transfected: sc-111308 (B) 293 whole cell lysates.

MEF-2 (C-21) - sc-313 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MEF-2 (C-21): sc-313. Western blot analysis of MEF-2 expression in BC<sub>3</sub>H1 (A) whole cell lysate and rat brain tissue extract (B).

MEF-2 (D-6) - sc-55500 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MEF-2 (D-6): sc-55500. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing nuclear staining of epidermal cells, keratinocytes, Langerhans cells and Melanocytes.

MEF-2 (N-18) - sc-13917 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MEF-2 (N-18): sc-13917. Western blot analysis of MEF-2 expression in non-transfected: sc-110760 (A) and human MEF-2 transfected: sc-111308 (B) 293 whole cell lysates.

MEF-2A (H-300) - sc-10794 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MEF-2A (H-300): sc-10794. Western blot analysis of MEF-2A expression in non-transfected: sc-110760 (A) and human MEF-2A transfected: sc-111308 (B) 293 whole cell lysates.

p-MEF-2 (B-11) - sc-377535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of MEF-2 phosphorylation in calyculin A treated (A,C) and calyculin A and lambda protein phosphatase (sc-200312A) treated (B,D) SH-SY5Y whole cell lysates. Antibodies tested include p-MEF-2 (B-11): sc-377535 (A,B) and MEF-2 (B-4): sc-17785 (C,D).

p-MEF-2 (Thr 312) - sc-101732 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-MEF-2 (Thr 312): sc-101732. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear localization.

p-MEF-2 (Ser 408) - sc-101731 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-MEF-2 (Ser 408): sc-101731. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear localization.

Anti-MEF2A (phospho S408) antibody - ab51151 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
This image shows human breast carcinoma tissue stained with ab51151 at 1/50 dilution. The cells in the right hand image were treated with the immunising phosphopeptide, the cells in the left hand image were not.

Anti-MEF2A (phospho T312) antibody - ab30644 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MEF2A (phospho T312) antibody (ab30644) at 1/1000 dilution + Mouse liver tissue lysate - whole at 40 µgSecondaryHRP-conjugated goat anti-rabbit IgG polyclonal at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-MEF2A (phospho T319) antibody - ab52156 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MEF2A (phospho T319) antibody (ab52156) at 1/500 dilutionLane 1 : extracts from K562 cells treated with UV (15 mins), with phosphopeptideLane 2 : extracts from K562 cells treated with UV (15 mins), without phosphopeptide

Anti-MEF2A (phospho T319) antibody - ab195823 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MEF2A (phospho T319) antibody (ab195823) at 1/500 dilutionLane 1 : UV treated K562 whole cell lysates with antigen-specific peptideLane 2 : UV treated K562 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-MEF2A antibody - ab32866 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Ab32866 staining human heart muscle. Staining is localised to the nucleus.Left panel: with primary antibody. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 antigen retrieval buffer citrate pH 6.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-MEF2A antibody - ab51153 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MEF2A antibody (ab51153) at 1/500 dilutionLane 1 : extracts from Hela cells treated with 125ng/ml PMA for 30min, without immunizing peptideLane 2 : extracts from Hela cells treated with 125ng/ml PMA for 30min, with immunizing peptide

Anti-MEF2A antibody - ab86755 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MEF2A antibody (ab86755) at 1/100 dilution + Mouse brain tissue lysates at 35 µg

Anti-MEF2A antibody - ab30668 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab30668, at a dilution of 1/50, staining MEF2A (phospho T312) in paraffin embedded breast carcinoma tissue by Immunohistochemistry. Left image: Untreated. Right image: The same antibody preincubated with immunizing peptide.

Anti-MEF2A antibody - ab55547 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
MEF2A antibody (ab55547) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.

Anti-MEF2A antibody - ab82839 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MEF2A antibody (ab82839) at 1/1000 dilutionLane 1 : uninduced culture of E.coli (one shot Top10 competent cells) induced culture of E.coli (one shot Top10 competent cells)Lane 2 : induced culture of E.coli (one shot Top10 competent cells) induced culture of E.coli (one shot Top10 competent cells)Secondaryanti-Rabbit IgG HRP at 1/1000 dilution

Anti-MEF2A antibody - ab31172 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab31172 at a 1:100 dilution staining MEF2A in human brain by Immunohistochemistry, Formalin Fixed Paraffin Embedded Tissue.

Anti-MEF2A antibody - ab39420 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab39420, at a 1/100 dilution, staining human MEF2A in breast carcinoma tissue by Immunohistochemistry, Paraffin embedded tissue.

Anti-MEF2A antibody [1A10] - ab117555 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1A10
Anti-MEF2A antibody [1A10] (ab117555) at 1/500 dilution + Human lung cancer lysate

Anti-MEF2A antibody [1D11] - ab117575 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1D11
Immunohistochemical analysis of MEF2A expression in Formalin-Fixed, Paraffin-Embedded Human Prostate tissue using 2.5 µg/ml ab117575.

Anti-MEF2A antibody [3F6] - ab117573 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3F6
Immunohistochemical analysis of MEF2A expression in Formalin-Fixed, Paraffin-Embedded Human Prostate using 2.5 µg/ml ab117573.
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